Hello Bio/DNQX/HB0261/10mg-免疫在线蚂蚁淘旗下平台

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商品详细Hello Bio/DNQX/HB0261/10mg

Hello Bio/DNQX/HB0261/10mg

商品编号： HB0261-10mg

品牌： hellobio

市场价： ¥526.50

美元价： 405.00

产地：美国(厂家直采)

公司：

产品分类：酸碱缓冲液

公司分类： acid_base_buffer_solution

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Productoverview

Name
DNQX
Shortdescription
Selective,competitiveAMPA/kainatereceptorantagoNIST
BIOLOGicaldescription
SelectiveandcompetitiveAMPAandkainatereceptorantagonist.AlsoactsaspartialAMPAagonistinthepresenceofγ2transmembraneAMPAreceptorregulatoryproteins(TARP)subunit.Aneurolepticagentthatdisplayspro-oxidantactivity.
Biologicalaction
Antagonist
Purity
>98%
Ourproductsinaction
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Properties

Chemicalname
6,7-Dinitroquinoxaline-2,3-dione
MolecularWeight
252.14
Chemicalstructure
MolecularFormula
C₈H₄N₄O₆
CASNumber
2379-57-9
PubChemidentifier
3899541
SMILES
C1=C2C(=CC(=C1[N+](=O)[O-])[N+](=O)[O-])NC(=O)C(=O)N2
Source
Synthetic
InChi
InChI=1S/C8H4N4O6/c13-7-8(14)10-4-2-6(12(17)18)5(11(15)16)1-3(4)9-7/h1-2H,(H,9,13)(H,10,14)
InChiKey
RWVIMCIPOAXUDG-UHFFFAOYSA-N
MDLnumber
MFCD00069257
Appearance
Paleyellowsolid

Applications

Applicationnotes
DNQXantagonizestheactionsofglutamateatAMPAreceptors.Itiscommonlyusedtoreduceexcitatorypostsynapticcurrents(EPSC)andiscommonlyusedat10μM.DNQXdisodiumsaltfromHelloBiocompletelyblocksbothspontaneousandevokedEPSCsat10μM,withconcentrationsof1μMalsoeffective(seeFig1above).

#Protocol1:Evokedandspontaneousexcitatorypostsynapticcurrents(EPSCs)
- WholecellvoltageclamprecordingswereobtainedfromlayerVneuronsofthemouseprelimbiccortexbrainslice.
- EPSCswereevokedviaastimulatingelectrodeplacedinlayersII/IIIdeliveringasinglesquare(150μs)pulseevery10secatanintensitythatgaveareliableEPSC.
- Neuronswereheldat-70to-60mV(thereversalpotentialofGABAcurrents).EPSCswerecontinuouslystimulatedandrecordedinresponseto5minapplicationsofvaryingconcentrationsofNBQXdisodiumsaltuntilcompletereceptorinhibition.
- SpontaneousEPSCswererecordedbeforeandafteradditionofNBQXdisodiumsaltbyholdingtheneuronat-70mVandrecordingfor10sec.
- RecordingsforEPSCsweremadeintheabsenceofGABA_A-Rantagonists.

StoringandUsingYourProduct

Storageinstructions
Roomtemperature
Solubilityoverview
SolubleinDMSO(100mM)
Important
ThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.

ReferencesforDNQX

Redoxpropertiesandprooxidantcytotoxicityofaneurolepticagent6,7-dinitrodihydroquinoxaline-2,3-dione(DNQX).
ŠarlauskasJetal(2013)ActaBiochimPol60(2):227-31.
PubMedID:23757451
TARPauxiliarysubunitsswitchAMPAreceptorantagonistsintopartialagonists.
MenuzKetal(2007)Science318(5851):815-7.
PubMedID:17975069
SelectiveexcitatoryactionsofDNQXandCNQXinratthalamicneurons.
LeeSHetal(2010)JNeurophysiol103(4):1728-34.
PubMedID:20107128
Pharmacologicalcharacterizationofglutamatergicagonistsandantagonistsatrecombinanthumanhomomericandheteromerickainatereceptorsinvitro.
Altetal(2004)Neuropharmacology46(6):793-806
PubMedID:15033339

品牌介绍

Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.

公司介绍

品牌分类

拮抗剂和抑制剂抗生素激动剂和活化剂初级的染料和污渍

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QQ ：1570468124

手机：18915418616

官网：http://www.hellobio.com/

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