Hello Bio/DMH-1/HB3110/
市场价：
¥585.00
美元价：
450.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameDMH-1
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Short descriptionSelective ALK2 inhibitor. Promotes iPSC neurogenesis.
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Biological descriptionSelective ALK2 inhibitor (IC50 = 108 nM). Blocks BMP signaling. Also promotes human induced pluripotent stem cell (iPSC ) neurogenesis when used in combination with SB 431542. Shows antitumor activity.
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Biological actionInhibitor
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Purity>98%
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Properties
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Chemical name4-[6-[4-(1-Methylethoxy)phenyl]pyra zolo[1,5-a]pyrimidin-3-yl]-quinoline
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Molecular Weight380.44
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Chemical structure
![DMH-1 | [1206711-16-1]](images/hellobio/201710/hb3110.png "DMH-1 | [1206711-16-1]")
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Molecular FormulaC24H20N4O
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CAS Number1206711-16-1
Storing and Using Your Product
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Storage instructions+4°C
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Solubility overviewsoluble in DMSO (20mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for DMH-1
DMH1, a novel BMP small molecule inhibitor, increases cardiomyocyte progenitors and promotes cardiac differentiation in mouse embryonic stem cells.
Ao et al (2012) PLoS One 7(7) : e41627PubMedID: 22848549DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction.
Neely et al (2012) ACS Chem Neurosci 3(6) : 482-91PubMedID: 22860217DMH1, a small molecule inhibitor of BMP type i receptors, suppresses growth and invasion of lung cancer.
Hao et al (2014) PLoS One 9(6) : e90748PubMedID: 24603907
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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