Hello Bio/DMH-1/HB3110/10mg
商品编号：
HB3110-10mg
品牌：
hellobio
市场价：
¥1950.00
美元价：
1500.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameDMH-1
- ShortdescriptionSelectiveALK2inhibitor.PromotesiPSCneurogenesis.
- BIOLOGicaldescriptionSelectiveALK2inhibitor(IC50=108nM).BlocksBMPsignaling.Alsopromoteshumaninducedpluripotentstemcell(iPSC)neurogenesiswhenusedincombinationwithSB431542.Showsantitumoractivity.
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname4-[6-[4-(1-Methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline
- MolecularWeight380.44
- Chemicalstructure
![DMH-1 | [1206711-16-1]](images/hellobio/201710/hb3110.png "DMH-1 | [1206711-16-1]")
- MolecularFormulaC24H20N4O
- CASNumber1206711-16-1
StoringandUsingYourProduct
- Storageinstructions+4°C
- SolubilityoverviewsolubleinDMSO(20mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforDMH-1
DMH1,anovelBMPsmallmoleculeinhibitor,increasescardiomyocyteProgenitorsandpromotescardiacdifferentiationinmouseembryonicstemcells.
Aoetal(2012)PLoSOne7(7):e41627PubMedID:22848549DMH1,ahighlyselectivesmallmoleculeBMPinhibitorpromotesneurogenesisofhiPSCs:comparisonofPAX6andSOX1expressionduringneuralinduction.
Neelyetal(2012)ACSChemNeurosci3(6):482-91PubMedID:22860217DMH1,asmallmoleculeinhibitorofBMPtypeireceptors,suppressesgrowthandinvasionoflungcancer.
Haoetal(2014)PLoSOne9(6):e90748PubMedID:24603907
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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