Hello Bio/Disulfiram/HB1119/250mg
商品编号：
HB1119-50mg
品牌：
hellobio
市场价：
¥741.00
美元价：
570.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameDisulfiram
- ShortdescriptionReversIBLystimulatesSERCACa2+-ATPase.V-ATPaseinhibitor.
- BIOLOGicaldescriptionReversiblystimulatesSERCACa2+-ATPase.V-ATPaseinhibitor(EC50=24.8μM).Alsoinhibitsaldehydedehydrogenaseandmatrixmetalloproteinases(MMP-2and-9).InhibitsmultidrugresistantP-glycoproteinandconcanamycinA-sensitiveATP-hydrolysis.Displaysantifungal,anticancerandanti-alcoholactivity.
- BiologicalactionInhibitor
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameBis(diethylthiocarbamyoyl)disulfide
- MolecularWeight296.54
- Chemicalstructure
![Disulfiram [97-77-8]](images/hellobio/201710/hb1119.png "Disulfiram [97-77-8]")
- MolecularFormulaC10H20N2S4
- CASNumber97-77-8
- PubChemidentifier3117
- SMILESCCN(CC)C(=S)SSC(=S)N(CC)CC
- InChiInChI=1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3
- InChiKeyAUZONCFQVSMFAP-UHFFFAOYSA-N
- MDLnumberMFCD00009048
StoringandUsingYourProduct
- Storageinstructions+4°C
- SolubilityoverviewSolubleinDMSO(20mM)andinethanol(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforDisulfiram
Identificationofinhibitorsofvacuolarproton-translocatingATPasepumpsinyeastbyhigh-throughputscreeningflowcytometry.
JohnsonRMetal(2010)AnalBiochem398(2):203-11.PubMedID:20018164DisulfiramsuppressesinvasiveABIlityofosteosarcomacellsviatheinhibitionofMMP-2andMMP-9expression.
ChoHJetal(2007)JBiochemMolBiol40(6):1069-76.PubMedID:18047805Antifungalpotentialofdisulfiram.
KhanSetal(2007)NihonIshinkinGakkaiZasshi48(3):109-13.PubMedID:17667894Theethanolmetaboliteacetaldehydeincreasesparacellulardrugpermeabilityinvitroandoralbioavailabilityinvivo.
FisherSJetal(2010)JPharmacolExpTher332(1):326-33.PubMedID:19820208
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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