Hello Bio/2,5-Dimethyl-celecoxib/HB3717/25mg
市场价：
¥2944.50
美元价：
2265.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- Name2,5-Dimethyl-celecoxib
- ShortdescriptionShowsnoCOX-2inhibitoryfunction.Analogofcelecoxib.
- BIOLOGicaldescriptionClosestructuralanalogoftheselectivecyclooxygenase-2(COX-2)inhibitorcelecoxib,thatlacksCOX-2inhibitoryfunction.Anti-proliferative,anti-tumOrigenicandanti-angiogenic.Potentapoptosisinducerinmanycancercelllines.Down-regulatestheexpressionofsurvivin,cyclins,MMPsandinhibitscyclin-dependentkinaseactivity.ModulatesPDK-1,AKT,GSK3beta,p70S6K,PKAandMAPKAP-K1alpha.ReducesphosphorylationofERK1/2butnotAKTT-308orAKTS-473.Increasesintracellularfreecalciumlevelsandpotentlytriggerstheendoplasmaticreticulumstressresponse(ESR),activatingERstress-associatedproteinsGRP78/BiP,CHOP/GADD153andcaspase-4.
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname2,5-Dimethylcelecoxib
- MolecularWeight395.4
- Chemicalstructure
![2,5-Dimethyl-celecoxib [457639-26-8]](images/hellobio/201710/hb3717.png "2,5-Dimethyl-celecoxib [457639-26-8]")
- CASNumber457639-26-8
- InChiKeyNTFOSUUWGCDXEF-UHFFFAOYSA-N
- AppearanceWhitesolid
StoringandUsingYourProduct
- Storageinstructionsroomtemperature
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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