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Hello Bio/2,4-Diamino-6-hydroxypyrimidine/HB0070/250mg
Hello Bio/2,4-Diamino-6-hydroxypyrimidine/HB0070/250mg
商品编号：
HB0070-250mg
品牌：
hellobio
市场价：
¥4173.00
美元价：
3210.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- Name2,4-Diamino-6-hydroxypyrimidine
- ShortdescriptionGTPcyclohydrolaseI(GCH1)inhibitor
- BIOLOGicaldescriptionGTPcyclohydrolaseI(GCH1)inhibitor.Decreasestetrahydrobiopterin(BH4)synthesisandsuppressesNOSactivity.Alsocausesadecreaseinvascularcelladhesionmolecule1(VCAM-1)cellsinresponsetoTNF-αandIFN-γ.
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameDAHP
- MolecularWeight126.12
- Chemicalstructure
![2,4-Diamino-6-hydroxypyrimidine [56-06-4]](images/hellobio/201710/hb0070.png "2,4-Diamino-6-hydroxypyrimidine [56-06-4]")
- MolecularFormulaC4H6N4O
- CASNumber56-06-4
- PubChemidentifier2944
- SMILESC1(=CC(N=C(N1[H])N([H])[H])=O)N([H])[H]
StoringandUsingYourProduct
- Storageinstructions+4°C
- SolubilityoverviewsolubleinDMSOorwater
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
Referencesfor2,4-Diamino-6-hydroxypyrimidine
GTPcyclohydrolaseIinhibitionbytheprototypicinhibitor2,4-diamino-6-hydroxypyrimidine.MechanismsandunanticipatedroleofGTPcyclohydrolaseIfeedbackregulatoryprotein.
XieLetal(1998)JBiolChem273(33):21091-8.PubMedID:96948622,4-Diamino-6-hydroxypyrimidine(DAHP)suppressescytokine-inducedVCAM-1expressiononthecellsurfaceofhumanumbilicalveinendothelialcellsinaBH(4)-independentmanner.
IkemotoKetal(2008)BiochimBiophysActa1780(7-8):960-5.PubMedID:18423409ThemechanismofpotentGTPcyclohydrolaseIinhibitionby2,4-diamino-6-hydroxypyrimidine:requirementoftheGTPcyclohydrolaseIfeedbackregulatoryprotein.
KolinskyMAetal(2004)JBiolChem279(39):40677-82.PubMedID:15292175
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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