你好Bio/3-Deazaneplanocin A盐酸盐/HB1416/
市场价：
¥585.00
美元价：
450.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- Name3-DeazaneplanocinAhydrochloride
- ShortdescriptionHistonemethyltransferaseinhibitor.EnhancesOct4expressioninchemically-inducedpluripotentstemcells.
- BIOLOGicaldescriptionHistonemethyltransferaseinhibitor.InhibitsS-adenosylhomocysteinehydrolase(SAH)andEZH2proteinexpression.AlsoenhancesOct4expressioninchemically-inducedpluripotentstemcells.Showsanti-cancerandantiviralactions.
- AlternativenamesDZNep
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname(1S,2R,5R)-5-(4-Amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1,2-diolhydrochloride
- MolecularWeight298.73
- Chemicalstructure
![3-Deazaneplanocin A hydrochloride [120964-45-6]](images/hellobio/201710/hb1416.png "3-Deazaneplanocin A hydrochloride [120964-45-6]")
- MolecularFormulaC12H14N4O3.HCl
- CASNumber120964-45-6
StoringandUsingYourProduct
- Storageinstructions-20°C
- Solubilityoverviewsolubleinwater(10mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
Referencesfor3-DeazaneplanocinAhydrochloride
Synthesisof3-deazaneplanocinA,apowerfulinhibitorofS-adenosylhomocysteinehydrolasewithpotentandselectiveinvitroandinvivoantiviralactivities.
TsengCKetal(1989)JMedChem32(7):1442-6.PubMedID:25447213-DeazaneplanocinA(DZNep),aninhibitorofthehistonemethyltransferaseEZH2,inducesapoptosisandreducescellmigrationinchondrosarcomacells.
GirardNetal(2014)PLoSOne9(5):e98176.PubMedID:24852755InhibitionofhistonemethyltransferaseEZH2depletesleukemiastemcellofmixedlineageleukemiafusionleukemiathroughupregulationofp16.
UedaKetal(2014)CancerSci105(5):512-9.PubMedID:24612037
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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