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Hello Bio/3-Deazaneplanocin A hydrochloride/HB1416/5mg
Hello Bio/3-Deazaneplanocin A hydrochloride/HB1416/5mg
商品编号：
HB1416-5mg
品牌：
hellobio
市场价：
¥8190.00
美元价：
6300.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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Name3-Deazaneplanocin A hydrochloride
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Short descriptionHistone methyltransferase inhibitor. Enhances Oct4 expression in chemically-induced pluripotent stem cells.
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Biological descriptionHistone methyltransferase inhibitor. Inhibits S-adenosylhomocysteine hydrolase (SAH) and EZH2 protein expression. Also enhances Oct4 expression in chemically-induced pluripotent stem cells. Shows anti-cancer and antiviral actions.
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Alternative namesDZNep
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Biological actionInhibitor
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Purity>98%
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Our products in actionSubmit Your Citation Now
Properties
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Chemical name(1S,2R,5R)-5-(4-Amino-1H-imidazo[4, 5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene -1,2-diol hydrochloride
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Molecular Weight298.73
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Chemical structure
![3-Deazaneplanocin A hydrochloride [120964-45-6]](images/hellobio/201710/hb1416.png "3-Deazaneplanocin A hydrochloride [120964-45-6]")
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Molecular FormulaC12H14N4O3.HCl
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CAS Number120964-45-6
Storing and Using Your Product
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Storage instructions-20°C
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Solubility overviewsoluble in water (10mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for 3-Deazaneplanocin A hydrochloride
Synthesis of 3-deazaneplanocin A, a powerful inhibitor of S-adenosylhomocysteine hydrolase with potent and selective in vitro and in vivo antiviral activities.
Tseng CK et al (1989) J Med Chem 32(7) : 1442-6.PubMedID: 25447213-Deazaneplanocin A (DZNep), an inhibitor of the histone methyltransferase EZH2, induces apoptosis and reduces cell migration in chondrosarcoma cells.
Girard N et al (2014) PLoS One 9(5) : e98176.PubMedID: 24852755Inhibition of histone methyltransferase EZH2 depletes leukemia stem cell of mixed lineage leukemia fusion leukemia through upregulation of p16.
Ueda K et al (2014) Cancer Sci 105(5) : 512-9.PubMedID: 24612037
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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