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商品详细Hello Bio/DAPT/HB3345/5mg
Hello Bio/DAPT/HB3345/5mg
Hello Bio/DAPT/HB3345/5mg
商品编号: HB3345
品牌: hellobio
市场价: ¥1618.50
美元价: 1245.00
产地: 美国(厂家直采)
公司:
产品分类: 酸碱缓冲液
公司分类: acid_base_buffer_solution
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Productoverview

  • Name
    DAPT
  • Shortdescription
    γ-secretaseinhibitor.Alsoinducesneuronaldifferentiation.
  • BIOLOGicaldescription
    Cellpermeableγ-secretaseinhibitor.Blocksnotchsignaling.ReducesAβlevelsinvitroandinvivo(IC50valuesare115and200nMfortotalβ-amyloidandAβ1-42respectively).Enhancesneuronaldifferentiationindependentofhedgehog(Shh)signaling.Alsopromotesdifferentiationofneuralstem/Progenitorcellsintoneurons.
  • Biologicalaction
    Inhibitor
  • Purity
    >98%
  • Ourproductsinaction
    SubmitYourCitationNow

Properties

  • Chemicalname
    N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycinetbutylester
  • MolecularWeight
    432.5
  • Chemicalstructure
    DAPT [208255-80-5]
  • CASNumber
    208255-80-5
  • InChiKey
    DWJXYEABWRJFSP-XOBRGWDASA-N
  • Appearance
    Whitetooff-whitesolid

StoringandUsingYourProduct

  • Storageinstructions
    +4°C
  • Solubilityoverview
    SolubleinDMSO(100mM)
  • Important
    ThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.

ReferencesforDAPT

  • TheNotchsignalinginhibitorDAPTdown-regulatescdk5activityandmodulatesthedistributionofneuronalcytoskeletalproteins.

    Kanungoetal(2008)JNeuRochem106(5):2236-48
    PubMedID:18662245
  • ThenotchresponseinhibitorDAPTenhancesneuronaldifferentiationinembryonicstemcell-derivedembryoidbodiesindependentlyofsonichedgehogsignaling.

    CrawfordandRoelink(2007)DevDyn236(3):886-92
    PubMedID:17295317
  • Functionalgamma-secretaseinhibitorsreducebeta-amyloidpeptidelevelsinbrain.

    Doveyetal(2001)JNeurochem76(1):173-81
    PubMedID:11145990
  • Lingo-1shRNAandNotchsignalinginhibitorDAPTpromotedifferentiationofneuralstem/progenitorcellsintoneurons.

    Wangetal(2015)BrainRes8993(15):873-2
    PubMedID:26607252
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业,总部位于英国布里斯托尔,在美国普林斯顿设有分公司,主旨在于提供质优价廉的生命科学研究工具,主要产品线为小分子化合物,如激动剂、拮抗剂、抑制剂等,部分产品价格甚至低至其他供应商的50%。热销产品线:酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor,  NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632,  SB 431542 DAPT.