Hello Bio/Cyclosporin A/HB0220/100mg
商品编号：
HB0220-100mg
品牌：
hellobio
市场价：
¥1092.00
美元价：
840.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameCyclosporinA
- ShortdescriptionPotentcalcineurininhibitor.InhibitsMPTPopening.
- BIOLOGicaldescriptionPotentcalcineurininhibitor(IC50=5nM).InhibitsmitochondrialpermeABIlitytransitionpore(MPTP)openingandalsoP-glycoproteininhibitorandincreasesAKTactivation.Displaysimmunosuppressive,tumorpromotingandpro-angiogenicproperties.
- AlternativenamesCyclosporine;AntibioticS7481F1;CiclosporinA;CSA;cyclosporineA
- BiologicalactionInhibitor
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- MolecularWeight1202.63
- MolecularFormulaC62H111N11O12
- CASNumber59865-13-3
StoringandUsingYourProduct
- Storageinstructions-20°C(desiccate)
- SolubilityoverviewsolubleinDMSO(100mM)orethanol(50mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforCyclosporinA
CyclosporinAPromotesTumorAngiogenesisinaCalcineurin-IndependentMannerbyIncreasingMitochondrialReactiveOxygenSpecies.
ZhouAYetal(2014)MolCancerRes:PubMedID:25009293TheP-glycoproteininhibitorcyclosporinAdifferentiallyinfluencesbehaviouralandneuRochemicalresponsestotheantidepressantescitalopram.
O"BrienFEetal(2014)BehavBrainRes261:17-25.PubMedID:24280122CalcineurinphosphataseactivityinTlymphocytesisinhibitedbyFK506andcyclosporinA.
FrumanDAetal(1992)ProcNatlAcadSciUSA89(9):3686-90.PubMedID:1373887ImmunosuppressivecyclosporinAactivatesAKTinkeratinocytesthroughPTENsuppression:implicationsinskincarcinogenesis.
HanWetal(2010)JBiolChem285(15):11369-77.PubMedID:20154081
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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