Hello Bio/(R)-CPP/HB0021/10mg
商品编号：
HB0021-10mg
品牌：
hellobio
市场价：
¥3432.00
美元价：
2640.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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Name(R)-CPP
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Short descriptionPotent NMDA receptor antagonist
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Biological descriptionPotent NMDA receptor antagonist. Selective for GluN2A subtypes over GluN2B, GluN2C and GluN2D subtypes (Ki values are 41 nM, 0.27, 0.63 and 1.99 μM respectively). Blocks LTP induction, induces glutamate release and causes attention deficits in rats.
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Biological actionAntagonist
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Our products in actionSubmit Your Citation Now
Properties
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Chemical name3-((R)-2-Carboxypiperazin-4-yl)-propyl-1-phosphonic acid
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Molecular Weight252.21
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Chemical structure
![(R)-CPP [126453-07-4]](images/hellobio/201710/hb0021.png "(R)-CPP [126453-07-4]")
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Molecular FormulaC8H17N2O5P
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CAS Number126453-07-4
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PubChem identifier6603754
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SMILESC1CN(C[C@@H](N1)C(=O)O)CCCP(=O)(O)O
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InChiInChI=1S/C8H17N2O5P/c11-8(12)7-6-10(4-2-9-7)3-1-5-16(13,14)15/h7,9H,1-6H2,(H,11,12)(H2,13,14,15)/t7-/m1/s1
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InChiKeyCUVGUPIVTLGRGI-SSDOTTSWSA-N
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FormulationWhite solid
Storing and Using Your Product
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Storage instructionsRoom temperature (desiccate)
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Solubility overviewSoluble in water (100mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for (R)-CPP
Structure-activity analysis of a novel NR2C/NR2D-preferring NMDA receptor antagonist: 1-(phenanthrene-2-carbonyl) piperazine-2,3-dicarboxylic acid.
Feng B et al (2004) Br J Pharmacol 141(3) : 508-16.PubMedID: 14718249Long-term potentiation promotes proliferation/survival and neuronal differentiation of neural stem/progenitor cells.
Cho T et al (2013) PLoS One 8(10) : e76860.PubMedID: 24146937Sertindole restores attentional performance and suppresses glutamate release induced by the NMDA receptor antagonist CPP.
Carli M et al (2011) Psychopharmacology (Berl) 214(3) : 625-37.PubMedID: 21049266
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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