Hello Bio/CP-91149/HB0215/10mg
商品编号：
HB0215-10mg
品牌：
hellobio
市场价：
¥1989.00
美元价：
1530.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameCP-91149
- ShortdescriptionSyntheticGPinhibitor
- BIOLOGicaldescriptionSyntheticglycogenphosphorylase(GP)inhibitor(IC50=0.5µM).Approx5-to10-foldlesspotentintheabsenceofglucose.Alsoinhibitsglucagon-stimulatedglycogenolysis(IC50=2.1µM)andactivatesglycogensynthase.Displaysgrowthinhibitoryproperties.
- AlternativenamesCP-91,149
- BiologicalactionInhibitor
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname5-Chloro-N-[(1S,2R)-3-(dimethylamino)-2-hydroxy-3-oxo-1-(phenylmethyl)propyl]-1H-indole-2-carboxamide
- MolecularWeight399.87
- Chemicalstructure
![CP-91149 [186392-40-5]](images/hellobio/201710/hb0215.png "CP-91149 [186392-40-5]")
- MolecularFormulaC21H22ClN3O3
- CASNumber186392-40-5
StoringandUsingYourProduct
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforCP-91149
Inhibitionofglycogenphosphorylase(GP)byCP-91,149inducesgrowthinhibitioncorrelatingwithbrainGPexpression.
SchnierJBetal(2003)BiochemBiophysResCommun309(1):126-34.PubMedID:12943673Discoveryofahumanliverglycogenphosphorylaseinhibitorthatlowersbloodglucoseinvivo.
MartinWHetal(1998)ProcNatlAcadSciUSA95(4):1776-81.PubMedID:9465093Hepaticglycogensynthesisishighlysensitivetophosphorylaseactivity:evidencefrommetaboliccontrolanalysis.
AistonSetal(2001)JBiolChem276(26):23858-66.PubMedID:11309391
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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