Hello Bio/CP 690550 citrate/HB1427/10mg
商品编号：
HB1427-10mg
品牌：
hellobio
市场价：
¥1657.50
美元价：
1275.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameCP690550citrate
- ShortdescriptionPotentJAKinhibitor
- BIOLOGicaldescriptionPotentJAKinhibitor.InhibitsJAK3,JAK2andJAK1(IC50valuesare1,20and112nMrespectively).Reducespro-inflammatorycytokinerelease.Showsimmunosuppressantactions.
- AlternativenamesTofacitinibcitrate
- BiologicalactionInhibitor
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname(3R,4R)-4-Methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-β-oxo-1-piperidinepropanenitrilecitrate
- MolecularWeight504.49
- Chemicalstructure
![CP 690550 citrate [540737-29-9]](images/hellobio/201710/hb1427.png "CP 690550 citrate [540737-29-9]")
- MolecularFormulaC16H20N6O.C6H8O7
- CASNumber540737-29-9
StoringandUsingYourProduct
- Storageinstructions+4°C
- SolubilityoverviewsolubleinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforCP690550citrate
Examiningthechirality,conformationandselectivekinaseinhibitionof3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile(CP-690,550).
JiangJKetal(2008)JMedChem51(24):8012-8.PubMedID:19053756CP-690550TreatmentAmelioratesEstablishedDiseaseandProvidesLong-TermTherapeuticEffectsinanSKGArthritisModel.
OhKetal(2013)ImmuneNetw13(6):257-63.PubMedID:24385944DiscoveryofCP-690,550:apotentandselectiveJanuskinase(JAK)inhibitorforthetreatmentofautoimmunediseasesandorgantransplantrejection.
FlanaganMEetal(2010)JMedChem53(24):8468-84.PubMedID:21105711
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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