Hello Bio/CP 465022 hydrochloride/HB0214/50mg
商品编号：
HB0214-50mg
品牌：
hellobio
市场价：
¥6318.00
美元价：
4860.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameCP465022hydrochloride
- ShortdescriptionPotent,non-competitiveAMPAreceptorantagoNIST
- BIOLOGicaldescription
Potentandnon-competitiveAMPAreceptorantagonist(IC50=25nM).WeaklyinhibitsNMDA,GABAandkainatereceptors.Displaysanticonvulsantactions.
ThisproductisamixtureoftheactiveisomerCP465022andtheinactiveisomerCP465021.ThemixtureitselfisalsoknownasCP392110.Pleasenotethatthereisconfusioninthelifesciencemarketplaceandscientificliteratureregardingthecorrectnamingofthisproductandtypically,wheretheproductiscitedasCP465022,itisgenerallythemixtureofbothisomersthatisbeingreferredto.Ifyouneedanyfurtherclarification,pleasecontactcustomercare@hellobio.com
- AlternativenamesCP392110
- BiologicalactionAntagonist
- Purity>99%
- Customercomments
Goodprice,fastdeliveryVerifiedcustomer,UniversityofCopenhagen
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride
- MolecularWeight499.41
- Chemicalstructure
![CP 465022 hydrochloride [199655-36-2]](images/hellobio/201710/hb0214.png "CP 465022 hydrochloride [199655-36-2]")
- MolecularFormulaC26H24ClFN4O.HCl
- CASNumber199655-36-2
- PubChemidentifier67241566
- SMILESCCN(CC)CC1=CC=CC(=N1)C=CC2=NC3=C(C=C(C=C3)F)C(=O)N2C4=CC=CC=C4Cl.Cl
- InChiInChI=1S/C26H24ClFN4O.ClH/c1-3-31(4-2)17-20-9-7-8-19(29-20)13-15-25-30-23-14-12-18(28)16-21(23)26(33)32(25)24-11-6-5-10-22(24)27;/h5-16H,3-4,17H2,1-2H3;1H
- InChiKeyYKYDGCRJPYLXHY-UHFFFAOYSA-N
StoringandUsingYourProduct
- StorageinstructionsRoomtemperature(desiccate)
- SolubilityoverviewSolubleinwater(10mM)andinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforCP465022hydrochloride
Characterizationofthebindingsiteforanovelclassofnoncompetitivealpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionicacidreceptorantagonists.
MennitiFSetal(2000)MolPharmacol58(6):1310-7.PubMedID:11093768CP-465,022,aselectivenoncompetitiveAMPAreceptorantagonist,blocksAMPAreceptorsbutisnotneuroprotectiveinvivo.
MennitiFSetal(2003)Stroke34(1):171-6.PubMedID:12511770FunctionalcharacterizationofCP-465,022,aselective,noncompetitiveAMPAreceptorantagonist.
LazzaroJTetal(2002)Neuropharmacology42(2):143-53.PubMedID:11804610
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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