Hello Bio/ω-Conotoxin GVIA/HB1218/1mg
商品编号：
HB1218-1mg
品牌：
hellobio
市场价：
¥6415.50
美元价：
4935.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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Nameω-Conotoxin GVIA
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Short descriptionPotent, selective Cav2.2 (N-type) channel blocker
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Biological descriptionPeptide toxin. Potent, selective, partially reversible Cav2.2 (N-type) channel blocker (IC50 = 0.15 nM). Binds Cav2.2 α1 subunit (α1B). Inhibits synaptic plasticity and shows hypotensive and bradycardic actions.
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Alternative namesω-CTX, ω-CgTx; SNX-124
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Biological actionBlocker
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Purity>98%
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Net peptide content73% (this peptide is sold by gross weight)
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Special requirementsAs this product is a toxin, customers are required to complete a short end user declaration when ordering. Our customer care team will be happy to help you with this.
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Our products in actionSubmit Your Citation Now
Properties
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Chemical nameH-Cys(1)-Lys-Ser-Hyp-Gly-Ser-Ser-Cys(2)-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys(3)-Cys(1)-Arg-Ser-Cys(2)-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys(3)-Tyr-NH2 trifluoroacetate salt
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Molecular Weight3037
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Molecular FormulaC120H182N38O43S6
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CAS Number106375-28-4
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PubChem identifier16133838
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SMILESC[C@H]([C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@@H](NC(=O)[C@@H]4CSSC[C@@H](C(=O)N[C@H](C(=O)N5C[C@@H](C[C@H]5C(=O)N1)O)CO)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H]6C[C@H](CN6C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N4)CO)CCCNC(=N)N)NC2=O)N)CCCCN)CO)O)CO)CO)CC(=O)N)O)CC7=CC=C(C=C7)O)[C@@H](C)O)CCCCN)CCCNC(=N)N)C(=O)N[C@@H](CC8=CC=C(C=C8)O)C(=O)N)CC(=O)N)CC9=CC=C(C=C9)O)CO)O
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InChiInChI=1S/C120H182N38O43S6/c1-53(165)91-114(197)138-66(10-4-6-26-122)95(178)136-68(12-8-28-132-120(129)130)98(181)149-81(107(190)139-69(93(126)176)29-55-13-19-58(167)20-14-55)49-204-207-52-84-110(193)153-80-48-203-202-47-64(123)94(177)135-65(9-3-5-25-121)9
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InChiKeyFDQZTPPHJRQRQQ-NZPQQUJLSA-N
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MDL numberMFCD00076620
Storing and Using Your Product
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Storage instructions-20°C (desiccate)
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Solubility overviewSoluble in water (1mg/ml)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for ω-Conotoxin GVIA
Complex structures between the N-type calcium channel (CaV2.2) and ω-conotoxin GVIA predicted via molecular dynamics.
Chen R et al (2013) Biochemistry 52(21) : 3765-72.PubMedID: 23651160Distinct mechanisms contribute to agonist and synaptically induced metabotropic glutamate receptor long-term depression.
Connelly et al (2011) Eur J Pharmacol 667(1-3) : 160-8PubMedID: 21575629The effect of omega-conotoxin GVIA on synaptic transmission within the nucleus accumbens and hippocampus of the rat in vitro.
Home and Kemp (1991) Br J Pharmacol 103(3) : 1733-9PubMedID: 1657265omega-Conotoxin reduces facilitation of transmitter release at the frog neuromuscular junction.
Zengel et al (1993) Brain Res 611(1) : 25-30PubMedID: 8100174
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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