Hello Bio/CI 994/HB1385/10mg
商品编号：
HB1385-10mg
品牌：
hellobio
市场价：
¥1150.50
美元价：
885.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameCI994
- ShortdescriptionPotent,selectiveHDACinhibitor
- BIOLOGicaldescriptionPotentandselectivehistonedeacetylase(HDAC)inhibitor.InhibitsHDAC1,3,6and8(IC50valuesare0.41,0.75,>100and>100µMrespectively).InduceshistoneH3hyperacetylationandcelldifferentiation.Showsanti-proliferativeandapoptoticactions.Cell-permeable.
- AlternativenamesCI-994
- BiologicalactionInhibitor
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname4-(Acetylamino)-N-(2-aminophenyl)benzamide
- MolecularWeight269.3
- Chemicalstructure
![CI 994 [112522-64-2]](images/hellobio/201710/hb1385.png "CI 994 [112522-64-2]")
- MolecularFormulaC15H15N3O2
- CASNumber112522-64-2
StoringandUsingYourProduct
- Storageinstructions+4°C
- SolubilityoverviewsolubleinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforCI994
DistinctpharmacologicalpropertiesofsecondgenerationHDACinhibitorswiththebenzamideorhydroxamateheadgroup.
BeckersTetal(2007)IntJCancer121(5):1138-48.PubMedID:17455259Modulationofhistoneacetylationby[4-(acetylamino)-N-(2-amino-phenyl)benzamide]inHCT-8coloncarcinoma.
KrakerAJetal(2003)MolCancerTher2(4):401-8.PubMedID:12700284InvitrostudyofCI-994,ahistonedeacetylaseinhibitor,innon-smallcelllungcancercelllines.
LopreviteMetal(2005)OncolRes15(1):39-48.PubMedID:15839304
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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