Hello Bio/Chromanol 293B/HB0988/10mg
商品编号：
HB0988-10mg
品牌：
hellobio
市场价：
¥1560.00
美元价：
1200.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameChromanol293B
- ShortdescriptionKv7.1channelblocker
- BIOLOGicaldescriptionKv7.1channelblocker(alsoknownastheslowdelayedrectifierorIKschannel).BlockstheK+current(IC50=1.8µM).SelectivefortheKCNQ1subunitcombinedwithKCNE3overKCNE1(IC50valuesare0.54and15.1µMrespectively).AlsoblockstheCFTRchloridecurrent(ICFTR)andKv4.3channelItotransientoutwardcurrent(IC50valuesare19and38µMrespectively).
- BiologicalactionBlocker
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalnametrans-N-[6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-ethanesulfonamide
- MolecularWeight324.39
- Chemicalstructure
![Chromanol 293B [163163-23-3]](images/hellobio/201710/hb0988.png "Chromanol 293B [163163-23-3]")
- MolecularFormulaC15H20N2O4S
- CASNumber163163-23-3
StoringandUsingYourProduct
- Storageinstructionsroomtemperature
- Solubilityoverviewsolubleinethanol(20mM)orDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforChromanol293B
Chromanol293B,ablockeroftheslowdelayedrectifierK+current(IKs),inhibitstheCFTRCl-current.
BachmannAetal(2001)NaunynSchmiedebergsArchPharmacol363(6):590-6.PubMedID:11414653Chromanol293Binhibitsslowlyactivatingdelayedrectifierandtransientoutwardcurrentsincanineleftventricularmyocytes.
SunZQetal(2001)JCardiovascElectrophysiol12(4):472-8.PubMedID:11332571Ancillarysubunitsandstimulationfrequencydeterminethepotencyofchromanol293BblockoftheKCNQ1potassiumchannel.
BettGCetal(2006)JPhysiol576(Pt3):755-67.PubMedID:16887873
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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