Hello Bio/CHIR 99021/HB1261/50mg
商品编号：
HB1261-50mg
品牌：
hellobio
市场价：
¥7936.50
美元价：
6105.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameCHIR99021
- ShortdescriptionPotent,selectiveGSK3inhibitor.Wntsignalingactivator.
- BIOLOGicaldescription
Potent,selectiveandATP-competitiveGSK-3inhibitor(IC50valuesare6.7and10nMforGSK-3βandGSK-3αrespectively).
Wntsignalingactivatorwhichiscommonlyusedwith PD032501aspartofthe2icondition.
ExhibitsnocrossreactivityagainstCDKsandexhibits>500-foldselectivityforGSK3overotherproteinkinasesand>800-foldselectivityover>20otherenzymesandreceptors.
Promotesself-renewalofembryonicstemcellsandenablesmouseembryonicfibroblast(MEF)reprogrammingintoiPSCs.
WatersolubleCHIR99021trihydrochloridealsoavailable. - AlternativenamesCHIR99021
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile
- MolecularWeight465.34
- Chemicalstructure
![CHIR 99021 [252917-06-9]](images/hellobio/201710/hb1261.png "CHIR 99021 [252917-06-9]")
- MolecularFormulaC22H18Cl2N8
- CASNumber252917-06-9
- PubChemidentifier9956119
- SMILESCC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N
- InChiInChI=1S/C22H18Cl2N8/c1-13-10-29-21(31-13)17-12-30-22(32-20(17)16-4-3-15(23)8-18(16)24)27-7-6-26-19-5-2-14(9-25)11-28-19/h4-5,8,10-12H,6-7H2,1H3,(H,26,28)(H,29,31)(H,27,30,32)
- InChiKeyAQGNHMOJWBZFQQ-UHFFFAOYSA-N
- MDLnumberMFCD11846251
StoringandUsingYourProduct
- Storageinstructions-20°C
- SolubilityoverviewSolubleinDMSO(20mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforCHIR99021
TherolesofNotch3onthecellproliferationandapoptosisinducedbyCHIR99021inNSCLCcelllines:afunctionallinkbetweenWntandNotchsignalingpathways.
LiCetal(2013)PLoSOne8(12):e84659.PubMedID:24367688Selectiveglycogensynthasekinase3inhibitorspotentiateinsulinactivationofglucosetransportandutilizationinvitroandinvivo.
RingDBetal(2003)Diabetes52(3):588-95.PubMedID:12606497Pleiotropyofglycogensynthasekinase-3inhibitionbyCHIR99021promotesself-renewalofembryonicstemcellsfromrefractorymousestrains.
YeSetal(2012)PLoSOne7(4):e35892.PubMedID:22540008
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
联络我们
