Hello Bio/Chelerythrine Chloride/HB0190/5mg
商品编号：
HB0190-5mg
品牌：
hellobio
市场价：
¥1072.50
美元价：
825.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameChelerythrineChloride
- ShortdescriptionPKCinhibitor
- BIOLOGicaldescriptionProteinkinaseC(PKC)inhibitor(IC50=660nM).Competitiveinhibitorofthephosphateacceptor,non-competitiveATPinhibitor.InhibitsBclXLfunction;inhibitsBclXL-BakBH3peptidebinding(IC50=1.5μM).Showsapoptoticandantitumoractions.
- AlternativenamesCHE
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridiniumchloride
- MolecularWeight383.83
- Chemicalstructure
![Chelerythrine Chloride [3895-92-9]](images/hellobio/201710/hb0190.png "Chelerythrine Chloride [3895-92-9]")
- MolecularFormulaC21H18ClNO4
- CASNumber3895-92-9
- PubChemidentifier72311
- SMILESC[N+]1=C2C(=C3C=CC(=C(C3=C1)OC)OC)C=CC4=CC5=C(C=C42)OCO5.Cl
StoringandUsingYourProduct
- Storageinstructions-20°C(desiccate)
- Solubilityoverviewsolubleinwater(10mM)orDMSO(10mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforChelerythrineChloride
ChelerythrineisapotentandspecificinhibitorofproteinkinaseC.
HerbertJMetal(1990)BiochemBiophysResCommun172(3):993-9.PubMedID:2244923InductionofapoptosisbychelerythrinechloridethroughmitochondrialpathwayandBcl-2familyproteinsinhumanhepatomaSMMC-7721cell.
ZhangZFetal(2011)ArchPharmRes34(5):791-800.PubMedID:21656365IdentificationofchelerythrineasaninhibitorofBclXLfunction.
ChanSLetal(2003)JBiolChem278(23):20453-6.PubMedID:12702731
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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