Hello Bio/Charybdotoxin/HB1052/100μg
商品编号：
HB1052-100μg
品牌：
hellobio
市场价：
¥4017.00
美元价：
3090.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameCharyBDotoxin
- ShortdescriptionPotent,selectiveKCachannelinhibitor
- BIOLOGicaldescriptionPotentandselectiveKCachannelinhibitor(Kd=3.5nM).DisplayshighaffinityforKv1.3.AlsoahomotetramericF425Hchannelblocker(Kd=48nM).FoundinvenomoftheLeiurusquinquestriatushebraeusscorpion.
- BiologicalactionInhibitor
- OurproductsinactionSubmitYourCitationNow
Properties
- MolecularWeight4295.95
- MolecularFormulaC176H277N57O55S7
- CASNumber95751-30-7
StoringandUsingYourProduct
- Storageinstructions-20°C(desiccate)
- Solubilityoverviewsolubleinwater(1mg/ml)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforCharybdotoxin
Purification,sequence,andmodelstructureofcharybdotoxin,apotentselectiveinhibitorofcalcium-activatedpotassiumchannels.
Gimenez-GallegoGetal(1988)ProcNatlAcadSciUSA85(10):3329-33.PubMedID:2453055Interactionofagitoxin2,charybdotoxin,andiberiotoxinwithpotassiumchannels:selectivitybetweenvoltage-gatedandMaxi-Kchannels.
GaoYDetal(2003)Proteins52(2):146-54.PubMedID:12833539ElectrostaticinteractionbetweencharybdotoxinandatetramericmutantofShakerK(+)channels.
ThompsonJetal(2000)BiophysJ78(5):2382-91.PubMedID:10777734Charybdotoxinandmargatoxinactingonthehumanvoltage-gatedpotassiumchannelhKv1.3anditsH399Nmutant:anexperimentalandcomputationalcomparison.
NikoueeAetal(2012)JPhysChemB116(17):5132-40.PubMedID:22490327
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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