Hello Bio/Chaetocin/HB1415/1mg
商品编号：
HB1415-1mg
品牌：
hellobio
市场价：
¥1618.50
美元价：
1245.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameChaetocin
- ShortdescriptionPotenthistonemethyltransferaseSUV39H1inhibitor
- BIOLOGicaldescriptionPotenthistonemethyltransferaseSUV39H1inhibitor(IC50=0.8µM).Inducesreactiveoxygenspecies.Showsapoptoticandanti-canceractions.
- BiologicalactionInhibitor
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname(3S,3"S,5aR,5aR,10bR,10"bR,11aS,11"aS)-2,2",3,3",5a,5"a,6,6"-octahydro-3,3"-bis(hydroxymethyl)-2,2"-dimethyl-[10b,10"b(11H,11"H)-bi3,11a-epidithio-11aH-pyrazino[1",2":1,5]pyrrolo[2,3-b]indole]-1,1",4,4"-tetrone
- MolecularWeight696.84
- Chemicalstructure
![Chaetocin [28097-03-2]](images/hellobio/201710/hb1415.png "Chaetocin [28097-03-2]")
- MolecularFormulaC30H28N6O6S4
- CASNumber28097-03-2
StoringandUsingYourProduct
- Storageinstructions-20°C
- SolubilityoverviewsolubleinDMSO(10mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforChaetocin
Replyto"Chaetocinisanonspecificinhibitorofhistonelysinemethyltransferases".
GreinerDetal(2013)NatChemBiol9(3):137PubMedID:23416388Chaetocin-inducedROS-mediatedapoptosisinvolvesATM-YAP1axisandJNK-dependentinhibitionofglucosemetabolism.
DixitDetal(2014)CellDeathDis5:e1212.PubMedID:24810048Theanticancereffectsofchaetocinareindependentofprogrammedcelldeathandhypoxia,andareassociatedwithinhibitionofendothelialcellproliferation.
IshamCRetal(2012)BrJCancer106(2):314-23.PubMedID:22187030Chaetocinisanonspecificinhibitorofhistonelysinemethyltransferases.
CherblancFLetal(2013)NatChemBiol9(3):136-7.PubMedID:23416387
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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