你好Bio/CGP 37157/HB1132/50mg
商品编号：
HB1132-50mg
品牌：
hellobio
市场价：
¥7507.50
美元价：
5775.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameCGP37157
- ShortdescriptionPotent,selectivemitochondriaNa+/Ca2+exchangeinhibitor
- BIOLOGicaldescriptionPotentandselectivemitochondriaNa+/Ca2+exchangeinhibitor(IC50=0.36µM).Alsoinhibitssarco/endoplasmicreticulumCa2+-stimulatedATPase(SERCA)andactivatesryanodinereceptorchannels(RyRs)(EC50valuesare9.4and12.0µMforcardiacandskeletalRyRsrespectively).Displaysneuroprotectiveproperties.
- BiologicalactionInhibitor
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one
- MolecularWeight324.22
- Chemicalstructure
![CGP 37157 [75450-34-9]](images/hellobio/201710/hb1132.png "CGP 37157 [75450-34-9]")
- MolecularFormulaC15H11Cl2NOS
- CASNumber75450-34-9
- PubChemidentifier2688
- SMILESC1C(=O)NC2=C(C=C(C=C2)Cl)C(S1)C3=CC=CC=C3Cl
- InChiInChI=1S/C15H11Cl2NOS/c16-9-5-6-13-11(7-9)15(20-8-14(19)18-13)10-3-1-2-4-12(10)17/h1-7,15H,8H2,(H,18,19)
- InChiKeyKQEPIRKXSUIUTH-UHFFFAOYSA-N
- MDLnumberMFCD09055422
StoringandUsingYourProduct
- StorageinstructionsRoomtemperature
- SolubilityoverviewSolubleinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforCGP37157
BenzothiazepineCGP37157anditsisosteric2"-methylanalogueprovideneuroprotectionandblockcellcalciumentry.
González-LafuenteLetal(2012)ACSChemNeurosci3(7):519-29.PubMedID:22860221CGP37157,aninhibitorofthemitochondrialNa+/Ca2+exchanger,protectsneuronsfromexcitotoxicitybyblockingvoltage-gatedCa2+channels.
RuizAetal(2014)CellDeathDis5:e1156.PubMedID:24722281SelectivityofinhibitionofNa(+)-Ca2+exchangeofheartmitochondriabybenzothiazepineCGP-37157.
CoxDAetal(1993)JCardiovascPharmacol21(4):595-9.PubMedID:7681905CGP-37157inhibitsthesarcoplasmicreticulumCa?+ATPaseandactivatesryanodinereceptorchannelsinstriatedmuscle.
NeumannJTetal(2011)MolPharmacol79(1):141-7.PubMedID:20923851
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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