你好Bio/Capsazepine/HB1040/10mg
商品编号：
HB1040-10mg
品牌：
hellobio
市场价：
¥1560.00
美元价：
1200.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameCapsazepine
- ShortdescriptionTRPV1channelantagoNIST
- BIOLOGicaldescriptionTRPV1channelantagonist(IC50=562nM).ConvertsN+,K+-ATPaseintoNa+-ATPase.Syntheticanalogofcapsaicinandcompetitivecapsaicinantagonist.Displaysanalgesicandanticonvulsantproperties.
- BiologicalactionAntagonist
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameN-[2-(4-Chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide
- MolecularWeight376.9
- Chemicalstructure
![Capsazepine [138977-28-3]](images/hellobio/201710/hb1040.png "Capsazepine [138977-28-3]")
- MolecularFormulaC19H21ClN2O2S
- CASNumber138977-28-3
- PubChemidentifier2733484
- SMILESC1CC2=CC(=C(C=C2CN(C1)C(=S)NCCC3=CC=C(C=C3)Cl)O)O
- InChiInChI=1S/C19H21ClN2O2S/c20-16-5-3-13(4-6-16)7-8-21-19(25)22-9-1-2-14-10-17(23)18(24)11-15(14)12-22/h3-6,10-11,23-24H,1-2,7-9,12H2,(H,21,25)
- InChiKeyDRCMAZOSEIMCHM-UHFFFAOYSA-N
- MDLnumberMFCD00153778
StoringandUsingYourProduct
- StorageinstructionsRoomtemperature
- SolubilityoverviewSolubleinethanol(25mM)andinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforCapsazepine
Capsazepine,asyntheticvanilloidthatconvertstheNa,K-ATPasetoNa-ATPase.
MahmmoudYA(2008)ProcNatlAcadSciUSA105(5):1757-61.PubMedID:18230728Functionalpropertiesofthehigh-affinityTRPV1(VR1)vanilloidreceptorantagonist(4-hydroxy-5-iodo-3-methoxyphenylacetateester)iodo-resiniferatoxin.
SeabrookGRetal(2002)JPharmacolExpTher303(3):1052-60.PubMedID:12438527Thediscoveryofcapsazepine,thefirstcompetitiveantagonistofthesensoryneuronexcitantscapsaicinandresiniferatoxin.
WalpoleCSetal(1994)JMedChem37(13):1942-54.PubMedID:8027976TRPV1antagonistcapsazepinesuppresses4-AP-inducedepileptiformactivityinvitroandelectrographicseizuresinvivo.
Gonzalez-ReyesLEetal(2013)ExpNeurol250:321-32.PubMedID:24145133
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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