Hello Bio/Cantharidic Acid/HB0167/10mg
商品编号：
HB0167-10mg
品牌：
hellobio
市场价：
¥2028.00
美元价：
1560.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameCantharidicAcid
- ShortdescriptionPotent,selectivePP2Ainhibitor
- BIOLOGicaldescriptionPotentandselectiveproteinphosphatase2A(PP2A)inhibitor(IC50=53nM).SelectiveforPP2AoverPP1(IC50=562nM).Potentiatescyclic-AMPResponseelementbinding(CREB)signalling(EC50=0.45µM).Increasestransductionofadenovirusvectors.Showsapoptoticactions.
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname2,3-Dimethyl-7-oxABIcyclo[2.2.1]heptane-2,3-dicarboxylicacid
- MolecularWeight214.21
- MolecularFormulaC10H14O5
- CASNumber28874-45-5
- PubChemidentifier121475
- SMILESC[C@]1([C@H]2CC[C@@H]([C@]1(C)C(=O)O)O2)C(=O)O
- InChiInChI=1S/C10H14O5/c1-9(7(11)12)5-3-4-6(15-5)10(9,2)8(13)14/h5-6H,3-4H2,1-2H3,(H,11,12)(H,13,14)/t5-,6+,9+,10-
- InChiKeyNMTNUQBORQILRK-XCVPVQRUSA-N
StoringandUsingYourProduct
- StorageinstructionsRoomtemperature
- SolubilityoverviewSolubleinDMSO(100mM)andinethanol(25mM,gentlewarming)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforCantharidicAcid
IdentificationofcompoundsthatpotentiateCREBsignalingaspossIBLeenhancersoflong-termmemory.
XiaMetal(2009)ProcNatlAcadSciUSA106(7):2412-7.PubMedID:19196967Suppressionofproteinphosphatase2AactivityenhancesAd5/F35adenovirustransductionefficiencyinnormalhumanBlymphocytesandinRajicells.
CayerMPetal(2012)JImmunolMethods376(1-2):113-24.PubMedID:22210093Structureactivityanalysisofthepro-apoptotic,antitumoreffectofnitrostyreneadductsandrelatedcompounds.
KaapSetal(2003)BiochemPharmacol65(4):603-10.PubMedID:12566088
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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