Hello Bio/Calphostin C/HB0160/1mg
商品编号：
HB0160-1mg
品牌：
hellobio
市场价：
¥11251.50
美元价：
8655.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameCalphostinC
- ShortdescriptionPotent,selectivePKCinhibitor.AlsoantagonizestheTcf/β-catenincomplex
- BIOLOGicaldescriptionPotentandselectivephoto-activatedPKCinhibitor(IC50=50nM).AntagonizestheTcf/β-catenincomplex.Inhibitsgliomatumourcellproliferationandprotectsthemyocardiumagainstischemicinjury.
- AlternativenamesUCN1028C|PKF115-584
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname(1R)-2-[12-[(2R)-2-(Benzoyloxy)propyl]-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl]-1-methylethylcarbonicacid4-hydroxyphenylester
- MolecularWeight790.76
- Chemicalstructure
![Calphostin C [121263-19-2]](images/hellobio/201710/hb0160.png "Calphostin C [121263-19-2]")
- MolecularFormulaC44H38O14
- CASNumber121263-19-2
- PubChemidentifier2533
- SMILESCC(CC1=C(C(=C2C(=O)C=C(C3=C4C(=CC(=O)C5=C(C(=C(C(=C45)C1=C32)CC(C)OC(=O)OC6=CC=C(C=C6)O)OC)O)OC)OC)O)OC)OC(=O)C7=CC=CC=C7
StoringandUsingYourProduct
- Storageinstructions+4°C(desiccate)
- SolubilityoverviewsolubleinDMSOorethanol
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforCalphostinC
TheeffectofcalphostinC,apotentphotodependentproteinkinaseCinhibitor,ontheproliferationofgliomacellsinvitro.
PollackIFetal(1997)JNeurooncol31(3):255-66.PubMedID:9049854TheroleofproteinkinaseinCischemic/reperfusedpreconditionedisolatedrathearts.
TosakiAetal(1996)JCardiovascPharmacol28(5):723-31.PubMedID:8945687Invitroeffectsofasmall-moleculeantagoNISToftheTcf/β-catenincomplexonendometrialandendometrioticcellsofpatientswithendometriosis.
MatsuzakiSetal(2013)PLoSOne8(4):e61690.PubMedID:23626717
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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