Hello Bio/Calmidazolium Chloride/HB0156/10mg
商品编号：
HB0156-10mg
品牌：
hellobio
市场价：
¥1677.00
美元价：
1290.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameCalmidazoliumChloride
- ShortdescriptionCalmodulin(CaM)antagoNIST
- BIOLOGicaldescriptionCalmodulin(CaM)antagonist.Inhibitscalmodulin-dependentphosphodiesterase(IC50 =0.15µM).AntagonisesCa2+-transportingATPasecalmodulin-inducedactivation(IC50 =0.35µM). Inhibitsadenylylcyclase,solublefusionprotein,ACIXandACV-ACIIfusionproteins.BlocksL-typecalciumchannelsaswellasvoltage-dependentNa+andK+channelcurrents;increasesintracellularcalcium.Showscytotoxicandapoptoticeffects.
- BiologicalactionAntagonist
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname1-[Bis(4-chlorophenyl)methyl]-3-[2-(2,4-dichlorophenyl)-2-(2,4-dichlorobenzyloxy)ethyl]-1H-imidazoliumchloride
- MolecularWeight687.7
- Chemicalstructure
![Calmidazolium Chloride [57265-65-3]](images/hellobio/201710/hb0156.png "Calmidazolium Chloride [57265-65-3]")
- MolecularFormulaC31H23Cl7N2O
- CASNumber57265-65-3
- PubChemidentifier644274
- SMILESC1=CC(=CC=C1C(C2=CC=C(C=C2)Cl)N3C=C[N+](=C3)CC(C4=C(C=C(C=C4)Cl)Cl)OCC5=C(C=C(C=C5)Cl)Cl)Cl.[Cl-]
StoringandUsingYourProduct
- Storageinstructions+4°C
- SolubilityoverviewsolubleinDMSO(100mM)orethanol(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforCalmidazoliumChloride
Comparisonofthecalmodulinantagonistscompound48/80andcalmidazolium.
GietzenK(1983)BiochemJ216(3):611-6.PubMedID:6141789Smallligandsmodulatingtheactivityofmammalianadenylylcyclases:anovelmodeofinhibitionbycalmidazolium.
HaunsøAetal(2003)MolPharmacol63(3):624-31.PubMedID:12606770Cardiotoxicityofcalmidazoliumchlorideisattributedtocalciumaggravation,oxidativeandnitrosativestress,andapoptosis.
KumarSetal(2009)FreeRADIcBiolMed47(6):699-709.PubMedID:19497364
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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