Hello Bio/BVT 948/HB0150/50mg
商品编号：
HB0150-50mg
品牌：
hellobio
市场价：
¥5908.50
美元价：
4545.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameBVT948
- ShortdescriptionNon-competitiveirreversIBLePTPinhibitor
- BIOLOGicaldescriptionNon-competitiveirreversibleproteintyrosinephosphatases(PTP)inhibitor(Ki=1.2µMforPTP-1B).InhibitsabroadspectrumofPTP"s(IC50valuesare0.9,1.7,0.09,1.5and0.7µMforPTP-1B,TCPTP,SHP-2,LARandYopHrespectively).InhibitsseveralcytochromeP450isoformsandsuppressesMMP-9andblocksTPA-inducedNF-κBactivation.ExhibitsnoactivityforMAPK.Enhancesinsulinsensitivity.Cellpermeable.
- BiologicalactionInhibitor
- OurproductsinactionSubmitYourCitationNow
Properties
- MolecularWeight241.25
- Chemicalstructure
![BVT 948 [39674-97-0]](images/hellobio/201710/hb0150.png "BVT 948 [39674-97-0]")
- MolecularFormulaC14H11NO3
- CASNumber39674-97-0
- PubChemidentifier6604934
- SMILESCC1(C2=C(C3=CC=CC=C3C(=O)C2=O)NC1=O)C
StoringandUsingYourProduct
- Storageinstructionsroomtemperature
- SolubilityoverviewsolubleinethanolorDMSO(50mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforBVT948
Oxidationofproteintyrosinephosphatasesasapharmaceuticalmechanismofaction:astudyusing4-hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione.
LiljebrisCetal(2004)JPharmacolExpTher309(2):711-9.PubMedID:14747616Proteintyrosinephosphatasecontrolsbreastcancerinvasionthroughtheexpressionofmatrixmetalloproteinase-9.
HwangBMetal(2013)BMBRep46(11):533-8.PubMedID:24152909
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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