Hello Bio/bpV(pic)/HB0147/25mg
商品编号：
HB0147-25mg
品牌：
hellobio
市场价：
¥2886.00
美元价：
2220.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NamebpV(pic)
- ShortdescriptionPotentPTPinhibitor
- BIOLOGicaldescriptionPotentproteinphosphotyrosinephosphatase(PTP)inhibitor(IC50valuesare12.7and61µMforPTP-βandPTP-1Brespectively).Alsoinhibitsphosphataseandtensinhomologue(PTEN)(IC50=31nM)andactivatesinsulin-receptorkinase(IRK).Displayscardioprotectiveandinsulin-mimeticproperties.
- BiologicalactionInhibitor
- Purity>90%
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameDipotassiumbisperoxo(picolinato)oxovanadate(V)
- MolecularWeight367.28
- Chemicalstructure
- MolecularFormulaK2[VO(O2)2C6H4NO2].2H2O
- PubChemidentifier16760324
- SMILESC1=CC=NC(=C1)C(=O)[O-].O.O.[OH-].OO.OO.[K+].[K+].[V]
StoringandUsingYourProduct
- Storageinstructions+4°C
- SolubilityoverviewsolubleinwaterorDMSO
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforbpV(pic)
PeroxovanADIumcompounds.Anewclassofpotentphosphotyrosinephosphataseinhibitorswhichareinsulinmimetics.
PosnerBIetal(1994)JBiolChem269(6):4596-604.PubMedID:8308031BisperoxovanadiumcompoundsarepotentPTENinhibitors.
SchmidACetal(2004)FEBSLett566(1-3):35-8.PubMedID:15147864Earlysignalingeventstriggeredbyperoxovanadium[bpV(phen)]areinsulinreceptorkinase(IRK)-dependent:specificityofinhibitionofIRK-associatedproteintyrosinephosphatase(s)bybpV(phen).
BandCJetal(1997)MolEndocrinol11(13):1899-910.PubMedID:9415395EffectsofbpV(pic)andbpV(phen)onH9c2cardiomyoblastsduringbothhypoxia/reoxygenationandH2O2-inducedinjuries.
TianYetal(2012)MolMedRep5(3):852-8.PubMedID:22200881
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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