Hello Bio/BIX 01294/HB1413/10mg
商品编号：
HB1413-10mg
品牌：
hellobio
市场价：
¥2008.50
美元价：
1545.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameBIX01294
- ShortdescriptionPotent,selectiveGLP/G9aHMTaseinhibitor.PotentiatesiPSCinduction.
- BIOLOGicaldescriptionPotentandselectiveG9a-likeprotein(GLP)andG9ahistonelysinemethyltransferase(HMTase)inhibitor(IC50valuesare0.7and1.9µMrespectively).Showsantimalarialandanti-canceractions.AlsopotentiatesiPSCinduction.
- AlternativenamesBIX-01294
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinaminetrihydrochloride
- MolecularWeight600.02
- Chemicalstructure
![BIX 01294 [1392399-03-9]](images/hellobio/201710/hb1413.png "BIX 01294 [1392399-03-9]")
- MolecularFormulaC28H38N6O2.3HCl
- CASNumber1392399-03-9
StoringandUsingYourProduct
- Storageinstructionsroomtemperature(desiccate)
- Solubilityoverviewsolubleinwater(100mM)orDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforBIX01294
ReversalofH3K9me2byasmall-moleculeinhibitorfortheG9ahistonemethyltransferase.
KubicekSetal(2007)MolCell25(3):473-81.PubMedID:17289593Small-moleculehistonemethyltransferaseinhibitorsdisplayrapidantimalarialactivityagainstallbloodstageformsinPlasmodiumfalciparum.
MalmquistNAetal(2012)ProcNatlAcadSciUSA109(41):16708-13.PubMedID:23011794StructuralbasisforG9a-likeproteinlysinemethyltransferaseinhibitionbyBIX-01294.
ChangYetal(2009)NatStructMolBiol16(3):312-7.PubMedID:19219047Euchromatichistonemethyltransferase2inhibitor,BIX-01294,sensitizeshumanpromyelocyticleukemiaHL-60andNB4cellstogrowthinhibitionanddifferentiation.
SavickieneJetal(2014)LeukRes38(7):822-9.PubMedID:24832370
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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