Hello Bio/Bisindolylmaleimide VIII/HB0141/10mg
商品编号：
HB0141-10mg
品牌：
hellobio
市场价：
¥5518.50
美元价：
4245.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameBisindolylmaleimideVIII
- ShortdescriptionPotent,selectivePKCinhibitor
- BIOLOGicaldescriptionPotentandselectiveproteinkinaseCinhibitor(IC50=158nM).DisplaysselectivityforPKC-αoverPKC-β1,PKC-βII,PKC-γandPKC-ε(IC50valuesare53,195,163,213,175nMrespectively).FacilitatesFas-mediatedapoptosisandenhancesDR5mediatedapoptosis.AlsoCDK2antagoNIST(IC50=600nM).
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameRo31-7549acetate
- MolecularWeight458.6
- Chemicalstructure
![Bisindolylmaleimide VIII [138516-31-1]](images/hellobio/201710/hb0141.png "Bisindolylmaleimide VIII [138516-31-1]")
- MolecularFormulaC24H22N4O2.C2H4O2
- CASNumber138516-31-1
- PubChemidentifier9868770
- SMILESCC(=O)O.CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)CCCN
StoringandUsingYourProduct
- SolubilityoverviewsolubleinDMSOorwater
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforBisindolylmaleimideVIII
BisindolylmaleimideVIIIfacilitatesFas-mediatedapoptosisandinhibitsTcell-mediatedautoimmunediseases.
ZhouTetal(1999)NatMed5(1):42-8.PubMedID:9883838Isoenzymespecificityofbisindolylmaleimides,selectiveinhibitorsofproteinkinaseC.
WilkinsonSEetal(1993)BiochemJ294(Pt2):335-7.PubMedID:8373348BisindolylmaleimideVIIIenhancesDR5-mediatedapoptosisthroughtheMKK4/JNK/p38kinaseandthemitochondrialpathways.
OhtsukaTetal(2002)JBiolChem277(32):29294-303.PubMedID:12034736Proteome-wideidentificationofcellulartargetsaffectedbybisindolylmaleimide-typeproteinkinaseCinhibitors.
BrehmerDetal(2004)MolCellProteomics3(5):490-500.PubMedID:14769951
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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