Hello Bio/Bisindolylmaleimide VIII/HB0141/5mg
商品编号：
HB0141-5mg
品牌：
hellobio
市场价：
¥3295.50
美元价：
2535.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
-
NameBisindolylmaleimide VIII
-
Short descriptionPotent, selective PKC inhibitor
-
Biological descriptionPotent and selective protein kinase C inhibitor (IC50 = 158 nM). Displays selectivity for PKC-α over PKC-β1, PKC-βII, PKC-γ and PKC-ε (IC50 values are 53, 195, 163, 213, 175 nM respectively). Facilitates Fas-mediated apoptosis and enhances DR5 mediated apoptosis. Also CDK2 antagonist (IC50 = 600 nM).
-
Biological actionInhibitor
-
Purity>98%
-
Our products in actionSubmit Your Citation Now
Properties
-
Chemical nameRo 31-7549 acetate
-
Molecular Weight458.6
-
Chemical structure
![Bisindolylmaleimide VIII [138516-31-1]](images/hellobio/201710/hb0141.png "Bisindolylmaleimide VIII [138516-31-1]")
-
Molecular FormulaC24H22N4O2.C2H4O2
-
CAS Number138516-31-1
-
PubChem identifier9868770
-
SMILESCC(=O)O.CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)CCCN
Storing and Using Your Product
-
Solubility overviewsoluble in DMSO or water
-
ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Bisindolylmaleimide VIII
Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases.
Zhou T et al (1999) Nat Med 5(1) : 42-8.PubMedID: 9883838Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C.
Wilkinson SE et al (1993) Biochem J 294 ( Pt 2) : 335-7.PubMedID: 8373348Bisindolylmaleimide VIII enhances DR5-mediated apoptosis through the MKK4/JNK/p38 kinase and the mitochondrial pathways.
Ohtsuka T et al (2002) J Biol Chem 277(32) : 29294-303.PubMedID: 12034736Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors.
Brehmer D et al (2004) Mol Cell Proteomics 3(5) : 490-500.PubMedID: 14769951
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
联络我们
