你好生物/双吲哚马来酰亚胺V/HB0138/25mg
商品编号：
HB0138-5mg
品牌：
hellobio
市场价：
¥4719.00
美元价：
3630.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameBisindolylmaleimideV
- ShortdescriptionSelectivePKC/S6Kinhibitor
- BIOLOGicaldescriptionSelectiveproteinkinaseC(PKC)inhibitor.Displayslowaffinityformuscarinic1receptor(Kd=100µM).Alsomitogen-stimulatedproteinkinasep70s6k/p85s6k(S6K)inhibitor(IC50=8.0µM).Displayscytoprotectiveeffects
- BiologicalactionInhibitor
- OurproductsinactionSubmitYourCitationNow
Properties
- MolecularWeight341.3
- Chemicalstructure
![Bisindolylmaleimide V [113963-68-1]](images/hellobio/201710/hb0138.png "Bisindolylmaleimide V [113963-68-1]")
- MolecularFormulaC21H15N3O2
- CASNumber113963-68-1
StoringandUsingYourProduct
- SolubilityoverviewsolubleinDMSOormethanol
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforBisindolylmaleimideV
BisindolylmaleimideIandVinhibitnecrosisinducedbyoxidativestressinavarietyofcellsincludingneurons.
AsakaiRetal(2002)NeurosciRes44(3):297-304.PubMedID:12413658Ro31-6045,theinactiveanalogueoftheproteinkinaseCinhibitorRo31-8220,blocksinvivoactivationofp70(s6k)/p85(s6k):implicationsfortheanalysisofS6Ksignalling.
Marmy-ConusNetal(2002)FEBSLett519(1-3):135-40.PubMedID:12023032Muscarinicinteractionsofbisindolylmaleimideanalogues.
LazarenoSetal(1998)EurJPharmacol360(2-3):281-4.PubMedID:9851596ThebisindolylmaleimideGF109203XisapotentandselectiveinhibitorofproteinkinaseC.
ToullecDetal(1991)JBiolChem266(24):15771-81.PubMedID:1874734
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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