Hello Bio/Bisindolylmaleimide V/HB0138/10mg
商品编号：
HB0138-10mg
品牌：
hellobio
市场价：
¥8229.00
美元价：
6330.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameBisindolylmaleimide V
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Short descriptionSelective PKC / S6K inhibitor
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Biological descriptionSelective protein kinase C (PKC) inhibitor. Displays low affinity for muscarinic 1 receptor (Kd = 100 µM). Also mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) inhibitor (IC50 = 8.0 µM). Displays cytoprotective effects
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Biological actionInhibitor
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Our products in actionSubmit Your Citation Now
Properties
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Molecular Weight341.3
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Chemical structure
![Bisindolylmaleimide V [113963-68-1]](images/hellobio/201710/hb0138.png "Bisindolylmaleimide V [113963-68-1]")
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Molecular FormulaC21H15N3O2
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CAS Number113963-68-1
Storing and Using Your Product
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Solubility overviewsoluble in DMSO or methanol
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Bisindolylmaleimide V
Bisindolylmaleimide I and V inhibit necrosis induced by oxidative stress in a variety of cells including neurons.
Asakai R et al (2002) Neurosci Res 44(3) : 297-304.PubMedID: 12413658Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70(s6k)/p85(s6k): implications for the analysis of S6K signalling.
Marmy-Conus N et al (2002) FEBS Lett 519(1-3) : 135-40.PubMedID: 12023032Muscarinic interactions of bisindolylmaleimide analogues.
Lazareno S et al (1998) Eur J Pharmacol 360(2-3) : 281-4.PubMedID: 9851596The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C.
Toullec D et al (1991) J Biol Chem 266(24) : 15771-81.PubMedID: 1874734
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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