你好生物/双吲哚马来酰亚胺IV/HB0137/5mg
商品编号：
HB0137-5mg
品牌：
hellobio
市场价：
¥2418.00
美元价：
1860.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameBisindolylmaleimideIV
- ShortdescriptionSelective,non-competitivePKC/PKAinhibitor
- BIOLOGicaldescriptionSelectiveandnon-competitiveproteinkinaseC(PKC)inhibitor(IC50=0.1µM).AlsoinhibitsproteinkinaseA(PKA)(IC50=2.0µM).BlocksPLC/PKCsignallingtoblockmelatonin-inducedpotentiationofglycinecurrentsintheretina.
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameArcyriarubinA
- MolecularWeight327.34
- Chemicalstructure
![Bisindolylmaleimide IV [119139-23-0]](images/hellobio/201710/hb0137.png "Bisindolylmaleimide IV [119139-23-0]")
- MolecularFormulaC20H13N3O2
- CASNumber119139-23-0
- PubChemidentifier2399
- SMILESC1=CC=C2C(=C1)C(=CN2)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54
StoringandUsingYourProduct
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforBisindolylmaleimideIV
InhibitorsofproteinkinaseC.1.2,3-Bisarylmaleimides.
DavisPDetal(1992)JMedChem35(1):177-84.PubMedID:1732526ActivesiteinhibitorsprotectproteinkinaseCfromdephosphorylationandstABIlizeitsmatureform.
GouldCMetal(2011)JBiolChem286(33):28922-30.PubMedID:21715334ProteinkinaseCmasksnitricoxidesynthaseactivityinvascularsmoothmuscleunderbasalconditions.
KlineLWetal(2004)JCardiovascPharmacol43(2):281-7.PubMedID:14716218ThebisindolylmaleimideGF109203XisapotentandselectiveinhibitorofproteinkinaseC.
ToullecDetal(1991)JBiolChem266(24):15771-81.PubMedID:1874734
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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