Hello Bio/Bisindolylmaleimide III/HB0136/5mg
商品编号：
HB0136-5mg
品牌：
hellobio
市场价：
¥1950.00
美元价：
1500.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameBisindolylmaleimide III
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Short descriptionSelective PKC inhibitor
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Biological descriptionSelective protein kinase C (PKC) inhibitor. Competitive NQO2 inhibitor (Ki = 16.5 µM) and Ste20-related kinase (SLK) inhibitor (IC50 = 170 nM). Shows inhibitory action at PKCα, MSK1, MAPKAP-K1β, S6K1 and AMPK. Also CDK2 inhibitor (IC50 = 2 µM).
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Biological actionInhibitor
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Purity>98%
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Our products in actionSubmit Your Citation Now
Properties
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Chemical nameBIM III
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Molecular Weight384.43
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Chemical structure
![Bisindolylmaleimide III [137592-43-9]](images/hellobio/201710/hb0136.png "Bisindolylmaleimide III [137592-43-9]")
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Molecular FormulaC23H20N4O2
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CAS Number137592-43-9
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PubChem identifier2398
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SMILESC1=CC=C2C(=C1)C(=CN2)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)CCCN
Storing and Using Your Product
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Solubility overviewsoluble in methanol or DMSO
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Bisindolylmaleimide III
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Davies SP et al (2000) Biochem J 351(Pt 1) : 95-105.PubMedID: 10998351Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors.
Brehmer D et al (2004) Mol Cell Proteomics 3(5) : 490-500.PubMedID: 14769951The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C.
Toullec D et al (1991) J Biol Chem 266(24) : 15771-81.PubMedID: 1874734
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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