你好生物/双吲哚马来酰亚胺II/HB0135/5mg
商品编号：
HB0135-5mg
品牌：
hellobio
市场价：
¥2203.50
美元价：
1695.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameBisindolylmaleimideII
- ShortdescriptionPotentPKCinhibitor
- BIOLOGicaldescriptionPotentproteinkinaseC(PKC)inhibitor(IC50=0.10µM).DisplayslessactivityatproteinkinaseA(PKA)andpyruvatekinase(PK)(IC50valuesare2.0and0.70µMrespectively).Alsoβ1.3subunitofKv1.5channelinhibitor(IC50=12.4µM)andnon-competitivenicotoniccholinergicreceptorantagoNIST(approxIC50=0.031µM).
- BiologicalactionInhibitor
- Purity>97%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname3-(1H-Indol-3-yl)-4-[1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione
- MolecularWeight438.52
- Chemicalstructure
![Bisindolylmaleimide II [137592-45-1]](images/hellobio/201710/hb0135.png "Bisindolylmaleimide II [137592-45-1]")
- MolecularFormulaC27H26N4O2
- CASNumber137592-45-1
- PubChemidentifier2397
- SMILESCN1CCCC1CCN2C=C(C3=CC=CC=C32)C4=C(C(=O)NC4=O)C5=CNC6=CC=CC=C65
StoringandUsingYourProduct
- Storageinstructions-20°C
- SolubilityoverviewsolubleinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforBisindolylmaleimideII
PKCinhibitionresultsinaKv1.5+Kvβ1.3pharmacologyclosertoKv1.5channels.
MacíasAetal(2014)BrJPharmacol:PubMedID:24946104Chromaffincellcatecholaminesecretion:bisindolylmaleimidecompoundsexhibitnovelandpotentantagonisteffectsatthenicotiniccholinergicreceptorinpheochromocytomacells.
MahataMetal(2002)MolPharmacol61(6):1340-7.PubMedID:12021395ThebisindolylmaleimideGF109203XisapotentandselectiveinhibitorofproteinkinaseC.
ToullecDetal(1991)JBiolChem266(24):15771-81.PubMedID:1874734
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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