Hello Bio/BIO/HB1259/10mg
商品编号：
HB1259-10mg
品牌：
hellobio
市场价：
¥2671.50
美元价：
2055.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameBIO
- ShortdescriptionPotentGSK-3α/βinhibitor.MaintainsESCself-renewalandpluripotency.
- BIOLOGicaldescriptionPotentGSK-3α/βinhibitor(IC50=5nM).ExhibitsreducedactivityatCDK1/cyclinB,CDK2/cyclinA,CDK4/cyclinD1,CDK5/p35,MAPKKandPKC-subunitα(IC50valuesare0.32,0.30,10,0.08,10and12μMrespectively).Inducesβ-cateninstABIlisationandprotectshippocampalneuronsfromAβoligomerdamage.AlsoinhibitsTyr276/216phosphorylationandreducesβ-cateninphosphorylation.Cellpermeable.Maintainsembryonicstemcellself-renewalandpluripotencyanddisplaysproliferationenhancingproperties.
- Alternativenames6-BIO;6BIO
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname(2"Z,3"E)-6-Bromoindirubin-3"-oxime
- MolecularWeight356.17
- Chemicalstructure
![BIO [667463-62-9]](images/hellobio/201710/hb1259.png "BIO [667463-62-9]")
- MolecularFormulaC16H10BrN3O2
- CASNumber667463-62-9
StoringandUsingYourProduct
- Storageinstructions+4°C
- SolubilityoverviewsolubleinDMSO(10mM)orethanol(10mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforBIO
CanonicalWntsignalingprotectshippocampalneuronsfromAβoligomers:roleofnon-canonicalWnt-5a/Ca(2+)inmitochondrialdynamics.
Silva-AlvarezCetal(2013)FrontCellNeurosci7:97PubMedID:23805073GSK-3-selectiveinhibitorsderivedfromTyrianpurpleindirubins.
MeijerLetal(2003)ChemBiol10(12):1255-66.PubMedID:14700633TheGSK-3inhibitorBIOpromotesproliferationinmammaliancardiomyocytes.
TsengASetal(2006)ChemBiol13(9):957-63.PubMedID:16984885
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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