Productoverview

• Name
  (+)-Bicuculline
• Shortdescription
  Prototypic,competitiveGABA_AreceptorantagoNIST
• BIOLOGicaldescription

  Prototypic,competitiveGABA_AreceptorantagonistwhichdisplacesGABAfromtheagonistbindingsitetopreventreceptoractivation. 

  AlsoactsasanegativeallostericinhibitorofchannelopeningtoinhibitGABA_Areceptoractivationbyanaestheticagents.

  
  ReversIBLyandcompetitivelyblocksGABA_Areceptormediatedcurrents.WidelyusedtoisolateglutamatereceptormediatedEPSCs(excitatorypostsynapticpotentials).

  
  Showsconvulsantactionandinducesepilepsy.

  Watersolublemethiodide, methochloride andmethobromide saltsalsoavailable.

• Alternativenames
  BIC
• Biologicalaction
  Antagonist
• Purity
  >99%
• Ourproductsinaction
  SubmitYourCitationNow

Properties

• Chemicalname
  [R-(R*,S*)]-6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)furo[3,4-e]-1,3-benzodioxol-8(6H)-one
• MolecularWeight
  367.36
• Chemicalstructure
  
• MolecularFormula
  C₂₀H₁₇NO₆
• CASNumber
  485-49-4
• PubChemidentifier
  10237
• SMILES
  CN1CCC2=CC3=C(C=C2[C@H]1[C@H]4C5=C(C6=C(C=C5)OCO6)C(=O)O4)OCO3
• InChi
  InChI=1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h4-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1
• InChiKey
  IYGYMKDQCDOMRE-ZWKOTPCHSA-N
• MDLnumber
  MFCD00005006

StoringandUsingYourProduct

• Storageinstructions
  +4°C
• Solubilityoverview
  Solubleinethanol(5mM,gentlewarming)andinDMSO(100mM)
• Important
  ThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.

Referencesfor(+)-Bicuculline

• Advantagesofanantagonist:bicucullineandotherGABAantagonists.

  JohnstonGA(2013)BrJPharmacol169(2):328-36.

  PubMedID:23425285

• DifferentialeffectsofiontophoreticinvivoapplicationoftheGABA(A)-antagonistsbicucullineandgabazineinsensorycortex.

  KurtSetal(2006)HearRes212(1-2):224-35.

  PubMedID:16442250

• [Bicucullineinhibitsairwayremodelinginamurinemodelofchronicasthma].

  ZhuTetal(2010)NanFangYiKeDaXueXueBao30(4):842-6.

  PubMedID:20423862