你好生物/（+）-荷包牡丹碱/HB0896/50mg
商品编号：
HB0896-50mg
品牌：
hellobio
市场价：
¥1482.00
美元价：
1140.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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Name(+)-Bicuculline
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Short descriptionPrototypic, competitive GABAA receptor antagonist
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Biological description
Prototypic, competitive GABAA receptor antagonist which displaces GABA from the agonist binding site to prevent receptor activation.
Also acts as a negative allosteric inhibitor of channel opening to inhibit GABAA receptor activation by anaesthetic agents.
Reversibly and competitively blocks GABAA receptor mediated currents. Widely used to isolate glutamate receptor mediated EPSCs (excitatory postsynaptic potentials).
Shows convulsant action and induces epilepsy.Water soluble methiodide, methochloride and methobromide salts also available.
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Alternative namesBIC
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Biological actionAntagonist
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Purity>99%
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Properties
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Chemical name[R-(R*,S*)]-6-(5,6,7,8-Tetrahydro-6 -methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)furo[3, 4-e]-1,3-benzodioxol-8(6H)-one
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Molecular Weight367.36
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Chemical structure
![(+)-Bicuculline [485-49-4]](images/hellobio/201710/hb0896.png "(+)-Bicuculline [485-49-4]")
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Molecular FormulaC20H17NO6
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CAS Number485-49-4
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PubChem identifier10237
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SMILESCN1CCC2=CC3=C(C=C2[C@H]1[C@H]4C5=C(C6=C(C=C5)OCO6)C(=O)O4)OCO3
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InChiInChI=1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h4-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1
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InChiKeyIYGYMKDQCDOMRE-ZWKOTPCHSA-N
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MDL numberMFCD00005006
Storing and Using Your Product
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Storage instructions+4°C
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Solubility overviewSoluble in ethanol (5mM, gentle warming) and in DMSO (100mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for (+)-Bicuculline
Advantages of an antagonist: bicuculline and other GABA antagonists.
Johnston GA (2013) Br J Pharmacol 169(2) : 328-36.PubMedID: 23425285Differential effects of iontophoretic in vivo application of the GABA(A)-antagonists bicuculline and gabazine in sensory cortex.
Kurt S et al (2006) Hear Res 212(1-2) : 224-35.PubMedID: 16442250[Bicuculline inhibits airway remodeling in a murine model of chronic asthma].
Zhu T et al (2010) Nan Fang Yi Ke Da Xue Xue Bao 30(4) : 842-6.PubMedID: 20423862
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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