Hello Bio/BCTC/HB1190/50mg
商品编号：
HB1190-50mg
品牌：
hellobio
市场价：
¥5479.50
美元价：
4215.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameBCTC
- ShortdescriptionPotent,selectiveTRPV1channelantagoNIST
- BIOLOGicaldescriptionPotentandselectiveTRPV1channelantagonist(IC50valuesare6.0and35nMforacid-andcapsaicin-inducedTRPV1channelsrespectively).AlsopotentTRPM8channelantagonist(IC50=143nM).Bloodbrainbarrierpermeable.Displaysanalgesicproperties.
- BiologicalactionAntagonist
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-piperazinecarboxamide
- MolecularWeight372.89
- Chemicalstructure
![BCTC [393514-24-4]](images/hellobio/201710/hb1190.png "BCTC [393514-24-4]")
- MolecularFormulaC20H25ClN4O
- CASNumber393514-24-4
- PubChemidentifier9929425
- SMILESCC(C)(C)C1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=C(C=CC=N3)Cl
- InChiInChI=1S/C20H25ClN4O/c1-20(2,3)15-6-8-16(9-7-15)23-19(26)25-13-11-24(12-14-25)18-17(21)5-4-10-22-18/h4-10H,11-14H2,1-3H3,(H,23,26)
- InChiKeyROGUAPYLUCHQGK-UHFFFAOYSA-N
- MDLnumberMFCD08690556
StoringandUsingYourProduct
- StorageinstructionsRoomtemperature
- SolubilityoverviewSolubleinDMSO(100mM)andinethanol(40mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforBCTC
UseandlimitationsofthreeTRPV-1receptorantagonistsonsmoothmusclesofanimalsandman:avoteforBCTC.
BenkoRetal(2012)EurJPharmacol674(1):44-50.PubMedID:22056835N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carbox-amide(BCTC),anovel,orallyeffectivevanilloidreceptor1antagonistwithanalgesicproperties:I.invitrocharacterizationandpharmacokineticproperties.
ValenzanoKJetal(2003)JPharmacolExpTher306(1):377-86.PubMedID:12721338N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine-1(2H)-carbox-amide(BCTC),anovel,orallyeffectivevanilloidreceptor1antagonistwithanalgesicproperties:II.invivocharacterizationinratmodelsofinflammatoryandneuropath
PomonisJDetal(2003)JPharmacolExpTher306(1):387-93.PubMedID:12721336ConservationoffunctionalandpharmacologicalpropertiesinthedistantlyrelatedtemperaturesensorsTRVP1andTRPM8.
WeilAetal(2005)MolPharmacol68(2):518-27.PubMedID:15911692
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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