Hello Bio/BCTC/HB1190/10mg
商品编号：
HB1190-10mg
品牌：
hellobio
市场价：
¥1365.00
美元价：
1050.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameBCTC
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Short descriptionPotent, selective TRPV1 channel antagonist
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Biological descriptionPotent and selective TRPV1 channel antagonist (IC50 values are 6.0 and 35 nM for acid- and capsaicin-induced TRPV1 channels respectively). Also potent TRPM8 channel antagonist (IC50 = 143 nM). Blood brain barrier permeable. Displays analgesic properties.
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Biological actionAntagonist
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Purity>98%
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Our products in actionSubmit Your Citation Now
Properties
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Chemical name4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-piperazinecarboxamide
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Molecular Weight372.89
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Chemical structure
![BCTC [393514-24-4]](images/hellobio/201710/hb1190.png "BCTC [393514-24-4]")
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Molecular FormulaC20H25ClN4O
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CAS Number393514-24-4
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PubChem identifier9929425
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SMILESCC(C)(C)C1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=C(C=CC=N3)Cl
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InChiInChI=1S/C20H25ClN4O/c1-20(2,3)15-6-8-16(9-7-15)23-19(26)25-13-11-24(12-14-25)18-17(21)5-4-10-22-18/h4-10H,11-14H2,1-3H3,(H,23,26)
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InChiKeyROGUAPYLUCHQGK-UHFFFAOYSA-N
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MDL numberMFCD08690556
Storing and Using Your Product
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Storage instructionsRoom temperature
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Solubility overviewSoluble in DMSO (100mM) and in ethanol (40mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for BCTC
Use and limitations of three TRPV-1 receptor antagonists on smooth muscles of animals and man: a vote for BCTC.
Benko R et al (2012) Eur J Pharmacol 674(1) : 44-50.PubMedID: 22056835N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. in vitro characterization and pharmacokinetic properties.
Valenzano KJ et al (2003) J Pharmacol Exp Ther 306(1) : 377-86.PubMedID: 12721338N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflammatory and neuropath
Pomonis JD et al (2003) J Pharmacol Exp Ther 306(1) : 387-93.PubMedID: 12721336Conservation of functional and pharmacological properties in the distantly related temperature sensors TRVP1 and TRPM8.
Weil A et al (2005) Mol Pharmacol 68(2) : 518-27.PubMedID: 15911692
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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