Hello Bio/Bafilomycin A1/HB1125/100μg
商品编号：
HB1125-100μg
品牌：
hellobio
市场价：
¥4173.00
美元价：
3210.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameBafilomycinA1
- ShortdescriptionHighlypotent,selectiveV-ATPaseinhibitor
- BIOLOGicaldescriptionHighlypotentandselectivevacuolar-typeprotontranslocatingATPase(V-ATPase)inhibitor(IC50=50pMforchromaffingranulemembranes).Displaysneuroprotective,pro-apoptoticandantibioticproperties.
- BiologicalactionAntibiotic
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname(3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one
- MolecularWeight622.84
- MolecularFormulaC35H58O9
- CASNumber88899-55-2
- PubChemidentifier6436223
- SMILESC[C@H]1C/C(=C/C=C/[C@@H]([C@H](OC(=O)/C(=C/C(=C/[C@H]([C@H]1O)C)/C)/OC)[C@@H](C)[C@H]([C@H](C)[C@]2(C[C@H]([C@@H]([C@H](O2)C(C)C)C)O)O)O)OC)/C
- InChiKeyXDHNQDDQEHDUTM-JQWOJBOSSA-N
- MDLnumberMFCD06795130
- AppearanceWhitetooff-white
StoringandUsingYourProduct
- Storageinstructions-20°C;
- SolubilityoverviewSolubleinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforBafilomycinA1
BafilomycinA1preventsmaturationofautophagicvacuolesbyinhibitingfusionbetweenautophagosomesandlysosomesinrathepatomacellline,H-4-II-Ecells.
YamamotoAetal(1998)CellStructFunct23(1):33-42.PubMedID:9639028BafilomycinA1inhibitschloroquine-induceddeathofcerebellargranuleneurons.
ShackaJJetal(2006)MolPharmacol69(4):1125-36.PubMedID:16391239Bafilomycins:aclassofinhibitorsofmembraneATPasesfrommicroorganisms,animalcells,andplantcells.
BowmanEJetal(1988)ProcNatlAcadSciUSA85(21):7972-6.PubMedID:2973058
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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