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Hello Bio/5-aza-2-deoxycytidine (Decitabine)/HB1356/50mg
Hello Bio/5-aza-2-deoxycytidine (Decitabine)/HB1356/50mg
商品编号：
HB1356-50mg
品牌：
hellobio
市场价：
¥7449.00
美元价：
5730.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- Name5-aza-2"-deoxycytidine(DecitABIne)
- ShortdescriptionDNAmethyltransferaseinhibitor
- BIOLOGicaldescriptionDNAmethyltransferaseinhibitor.PreventsDNAmethylationafterincorporationintoDNA.Enhanceshistonedeacetylase(HDAC)inhibitor-inducedapoptosis.Showsactionsagainstatherosclerosisandcancer.
- Alternativenames5-Aza-CdR,5-Aza-dC,5-Deoxy-2"-azacytidine;Decitabine;ZdCyd;DAC
- BiologicalactionInhibitor
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname4-Amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one
- MolecularWeight228.21
- MolecularFormulaC8H12N4O4
- CASNumber2353-33-5
StoringandUsingYourProduct
- Storageinstructions+4°C
- Solubilityoverviewsolubleinwater(50mM)orDMSO(50mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
Referencesfor5-aza-2"-deoxycytidine(Decitabine)
5-Azacytidineand5-aza-2"-deoxycytidineasinhibitorsofDNAmethylation:mechaNISTicstudiesandtheirimplicationsforcancertherapy.
ChristmanJK(2002)Oncogene21(35):5483-95.PubMedID:12154409InhibitingDNAMethylationby5-Aza-2"-deoxycytidineamelioratesatherosclerosisthroughsuppressingmacrophageinflammation.
CaoQetal(2014)Endocrinology155(12):4925-38.PubMedID:25251587DNAmethyltransferaseinhibitionenhancesapoptosisinducedbyhistonedeacetylaseinhibitors.
ZhuWGetal(2001)CancerRes61(4):1327-33.PubMedID:11245429Resistancetotumornecrosisfactor-relatedapoptosis-inducingligand(TRAIL)-inducedapoptosisinneuroblastomacellscorrelateswithalossofcaspase-8expression.
EggertAetal(2001)CancerRes61(4):1314-9.PubMedID:11245427
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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