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Hello Bio/5-aza-2-deoxycytidine (Decitabine)/HB1356/10mg
Hello Bio/5-aza-2-deoxycytidine (Decitabine)/HB1356/10mg
商品编号：
HB1356-10mg
品牌：
hellobio
市场价：
¥1891.50
美元价：
1455.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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Name5-aza-2'-deoxycytidine (Decitabine)
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Short descriptionDNA methyltransferase inhibitor
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Biological descriptionDNA methyltransferase inhibitor. Prevents DNA methylation after incorporation into DNA. Enhances histone deacetylase (HDAC) inhibitor-induced apoptosis. Shows actions against atherosclerosis and cancer.
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Alternative names5-Aza-CdR, 5-Aza-dC, 5-Deoxy-2'-azacytidine; Decitabine; ZdCyd; DAC
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Biological actionInhibitor
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Purity>99%
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Our products in actionSubmit Your Citation Now
Properties
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Chemical name4-Amino-1-(2-deoxy-β-D-erythro-pento furanosyl)-1,3,5-triazin-2(1H)-one
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Molecular Weight228.21
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Molecular FormulaC8H12N4O4
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CAS Number2353-33-5
Storing and Using Your Product
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Storage instructions+4°C
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Solubility overviewsoluble in water (50mM) or DMSO (50mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for 5-aza-2'-deoxycytidine (Decitabine)
5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy.
Christman JK (2002) Oncogene 21(35) : 5483-95.PubMedID: 12154409Inhibiting DNA Methylation by 5-Aza-2'-deoxycytidine ameliorates atherosclerosis through suppressing macrophage inflammation.
Cao Q et al (2014) Endocrinology 155(12) : 4925-38.PubMedID: 25251587DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors.
Zhu WG et al (2001) Cancer Res 61(4) : 1327-33.PubMedID: 11245429Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression.
Eggert A et al (2001) Cancer Res 61(4) : 1314-9.PubMedID: 11245427
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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