你好Bio/Ascomycin/HB0123/1mg
商品编号：
HB0123-1mg
品牌：
hellobio
市场价：
¥877.50
美元价：
675.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameAscomycin
- ShortdescriptionCalcineurinphosphataseinhibitor
- BIOLOGicaldescriptionCalcineurinphosphataseinhibitorthatbindstoFK506-bindingprotein12(FKBP12)(IC50=49nM).AlsosuppressesT-cells(IC50=3.9nM).Displaysneurogenerative,neuroprotectiveandanticonvulsantproperties.
- BiologicalactionInhibitor
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-8-Ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)tetrone
- MolecularWeight792.01
- Chemicalstructure
![Ascomycin [104987-12-4]](images/hellobio/201710/hb0123.png "Ascomycin [104987-12-4]")
- MolecularFormulaC43H69NO12
- CASNumber104987-12-4
StoringandUsingYourProduct
- Storageinstructions-20°C
- SolubilityoverviewsolubleinDMSO(50mM)orethanol(50mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforAscomycin
Geneticallyengineeredanalogsofascomycinfornerveregeneration.
RevillWPetal(2002)JPharmacolExpTher302(3):1278-85.PubMedID:12183690AscomycinandFK506:pharmacologyandtherapeuticpotentialasanticonvulsantsandneuroprotectants.
Sierra-ParedesGetal(2008)CNSNeurosciTher14(1):36-46.PubMedID:18482098Anticonvulsanteffectofthecalcineurininhibitorascomycinonseizuresinducedbypicrotoxinmicroperfusionintherathippocampus.
Vázquez-LópezAetal(2006)PharmacolBiochemBehav84(3):511-6.PubMedID:16872668
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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