你好Bio/Arctigenin/HB0119/100mg
商品编号：
HB0119-100mg
品牌：
hellobio
市场价：
¥7176.00
美元价：
5520.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameArctigenin
- ShortdescriptionPotentMAPkinasekinase(MKK/MEK)inhibitor
- BIOLOGicaldescriptionPotentMAPkinasekinase(MKK/MEK)inhibitor(IC50=1nMforMKK1/MEK1).Antiviral,anti-cancer,antioxidantandanti-inflammatorycompound.InhibitsiNOSexpressionbysuppressing1-κBαphosphorylationandnucleartranslocationofp65(IC50=10nM).Showsneuroprotectiveactions.
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname(3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2(3H)-furanone
- MolecularWeight372.42
- Chemicalstructure
![Arctigenin [7770-78-7]](images/hellobio/201710/hb0119.png "Arctigenin [7770-78-7]")
- MolecularFormulaC21H24O6
- CASNumber7770-78-7
StoringandUsingYourProduct
- Storageinstructions-20°C(desiccate)
- Solubilityoverviewsolubleinethanol(25mM,gentlewarming)orDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforArctigenin
Arctigeninprotectsculturedcorticalneuronsfromglutamate-inducedneurodegenerationbybindingtokainatereceptor.
JangYPetal(2002)JNeurosciRes68(2):233-40.PubMedID:11948668Potentinhibitionoflipopolysaccharide-inducIBLenitricoxidesynthaseexpressionbydibenzylbutyrolactonelignansthroughinhibitionofI-kappaBalphaphosphorylationandofp65nucleartranslocationinmacrophages.
ChoMKetal(2002)IntImmunopharmacol2(1):105-16.PubMedID:11789661Arctigeninanti-tumoractivityinbladdercancerT24celllinethroughinductionofcell-cyclearrestandapoptosis.
YangSetal(2012)AnatRec(Hoboken)295(8):1260-6.PubMedID:22619087Arctigenin,aphenylpropanoiddibenzylbutyrolactonelignan,inhibitsMAPkinasesandAP-1activationviapotentMKKinhibition:theroleinTNF-alphainhibition.
ChoMKetal(2004)4(10-11):1419-29PubMedID:15313439
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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