
你好Bio/DL-AP5钠盐/HB0252/50mg
商品编号:
HB0252-50mg
品牌:
hellobio
市场价:
¥2886.00
美元价:
2220.00
产品分类:
酸碱缓冲液
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Productoverview
- NameDL-AP5sodiumsalt
- ShortdescriptionCompetitiveNMDAreceptorantagoNIST.Sodiumsalt.
- BIOLOGicaldescription
CompetitiveNMDAreceptorantagonist.Sodiumsalt.Bindsattheglutamatesite.Impairslearningandfearconditioning.DL-AP5alsoavailable.
- AlternativenamesDL-APVsodiumsalt
- BiologicalactionAntagonist
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Images
Properties
- ChemicalnameDL-2-Amino-5-phosphonopentanoicacidsodiumsalt
- MolecularWeight219.11
- Chemicalstructure
- MolecularFormulaC5H11NNaO5P
- CASNumber1303993-72-7
- PubChemidentifier52974251
- SMILESC(CC(C(=O)O)N)CP(=O)(O)[O-].[Na+]
- SourceSynthetic
- InChiInChI=1S/C5H12NO5P.Na/c6-4(5(7)8)2-1-3-12(9,10)11;/h4H,1-3,6H2,(H,7,8)(H2,9,10,11);/q;+1/p-1
- InChiKeyKWRCYAPNGUCHOE-UHFFFAOYSA-M
- AppearanceWhitesolid
Applications
- Applicationnotes
DL-AP5sodiumsaltisawatersolubleNMDAreceptorantagonist.Itistypicallyusedataconcentrationof50–100µM.DL-AP5sodiumsaltfromHelloBioreducesevokedNMDARcurrentwithfullreceptorantagonismat50µM(seeFig1above),consistentwiththeliteratureforthiscompound.
#Protocol1:EvokedNMDARcurrentsat+40mV
- NMDARcurrentswererecordedviawholecellvoltageclamprecordingsofCA1pyramidalneuronsfromrathippocampalbrainslice.
- NMDARcurrentswereevokedviaastimulatingelectrodeplacedintheCA3regiontostimulatetheSchaffercollateralpathway.
- EachNMDARcurrentwasevokedviaasinglesquare(150µs)pulseevery10secatastimulusintensitythatgaveareliableNMDARcurrent.
- Neuronswereconstantlyheldat+40mVandNMDARcurrentsrecordedinresponsetocontinualbathapplicationsofNMDARantagonists.
- AllNMDARrecordingsweremadeinthepresenceofGABAA-RandAMPARantagonists.
StoringandUsingYourProduct
- StorageinstructionsRoomtemperature(desiccate)
- SolubilityoverviewSolubleinwater(100mM)
- HandlingHydroscopicsolid,contactwithairmaycausematerialtobecomesticky.Productperformanceshouldnotbeaffectedbutwerecommendstoringthematerialinasealedjar.
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforDL-AP5sodiumsalt
InfusionoftheNMDAreceptorantagonist,DL-APV,intothebasolateralamygdaladisruptslearningtofearanovelandafamiliarcontextaswellasrelearningtofearanextinguishedcontext.
LaurentVetal(2009)LearnMem16(1):96-105.PubMedID:19141468Thebasolateralamygdalaisnecessaryforlearningbutnotrelearningextinctionofcontextconditionedfear.
LaurentVetal(2008)LearnMem15(5):304-14.PubMedID:18463174ComparativeanalysisofdifferentcompetitiveantagonistsinteractionwithNR2AandNR2BsubunitsofNMDAionotropicglutamatereceptor.
BlaiseMCetal(2005)JMolModel11(6):489-502.PubMedID:15928921
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业,总部位于英国布里斯托尔,在美国普林斯顿设有分公司,主旨在于提供质优价廉的生命科学研究工具,主要产品线为小分子化合物,如激动剂、拮抗剂、抑制剂等,部分产品价格甚至低至其他供应商的50%。热销产品线:酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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