你好Bio/DL-AP5/HB0251/50mg-免疫在线蚂蚁淘旗下平台

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你好Bio/DL-AP5/HB0251/50mg

商品编号： HB0251-50mg

品牌： hellobio

市场价： ¥2203.50

美元价： 1695.00

产地：美国(厂家直采)

公司：

产品分类：酸碱缓冲液

公司分类： acid_base_buffer_solution

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Productoverview

Name
DL-AP5
Shortdescription
CompetitiveNMDAreceptorantagoNIST
BIOLOGicaldescription
DL-AP5isacompetitiveNMDAreceptorantagonistwhichbindsattheglutamatesite.
Impairslearningandfearconditioning.
WatersolubleDL-AP5sodiumsaltalsoavailable.
Alternativenames
DL-APV
Biologicalaction
Antagonist
Purity
>99%
Ourproductsinaction
2citationsSubmitYourCitationNow

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Properties

Chemicalname
DL-2-Amino-5-phosphonopentanoicacid
MolecularWeight
197.13
Chemicalstructure
MolecularFormula
C₅H₁₂NO₅P
CASNumber
76326-31-3
PubChemidentifier
1216
SMILES
NC(CCCP(=O)(O)O)C(=O)O
Source
Synthetic
InChi
InChI=1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)
InChiKey
VOROEQBFPPIACJ-UHFFFAOYSA-N
MDLnumber
MFCD00010515
Appearance
Whitesolid

Applications

Applicationnotes
DL-AP5fromHelloBioreducestheevokedNMDARcurrentatconcentrationsof1and10μMwithfullreceptorantagonismachievedat50μM(seeFig1above).Itwasdissolvedinwaterat10mM.

#Protocol1:EvokedNMDAreceptorcurrents
- WholecellvoltageclamprecordingswereobtainedfromlayerVneuronsofthemouseprelimbiccortexbrainslice.
- NMDAcurrentswereevokedviaastimulatingelectrodeplacedinlayersII/IIIandevokedbyasinglesquare(150μs)pulseevery10secatastimulusintensitythatgaveareliableNMDAcurrent.
- Neuronswerehelda+40mVtorelieveNMDAcurrentsfromtheirvoltage-dependentMg²⁺block.
- NMDAcurrentswerecontinuallystimulatedandrecordedinresponsetocontinualbathapplicationsofDL-AP5untilNMDAcurrentswerecompletelyabolished.
- AllNMDARrecordingsweremadeinthepresenceofGABA_A-RandAMPARantagonists.

StoringandUsingYourProduct

Storageinstructions
Roomtemperature
Solubilityoverview
Solubleinwater(10mM)or0.1MNaOH(100mM)
Important
ThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.

ReferencesforDL-AP5

InfusionoftheNMDAreceptorantagonist,DL-APV,intothebasolateralamygdaladisruptslearningtofearanovelandafamiliarcontextaswellasrelearningtofearanextinguishedcontext.
LaurentVetal(2009)LearnMem16(1):96-105.
PubMedID:19141468
Thebasolateralamygdalaisnecessaryforlearningbutnotrelearningextinctionofcontextconditionedfear.
LaurentVetal(2008)LearnMem15(5):304-14.
PubMedID:18463174
ComparativeanalysisofdifferentcompetitiveantagonistsinteractionwithNR2AandNR2BsubunitsofNMDAionotropicglutamatereceptor.
BlaiseMCetal(2005)JMolModel11(6):489-502.
PubMedID:15928921
Context-DependentModulationofExcitatorySynapticStrengthbySynapticallyReleasedZinc
KalappaandTzounopoulos(2017)eNeuro10.1523:0011-17

品牌介绍

Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.

公司介绍

品牌分类

拮抗剂和抑制剂抗生素激动剂和活化剂初级的染料和污渍

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官网：http://www.hellobio.com/

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