你好Bio/AP 18/HB1157/25mg
商品编号：
HB1157-25mg
品牌：
hellobio
市场价：
¥3217.50
美元价：
2475.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameAP18
- ShortdescriptionTRPA1channelantagoNIST
- BIOLOGicaldescriptionTRPA1channelantagonist(IC50valuesare3.1and4.5µMforhumanTRPA1andratTRPA1respectively).ExhibitslittleornoactivityforTRPV1-TRPV4channels.Reducescinnameldehyde-inducednociceptionbutnotcapsaicin-inducednociception.Alsopartiallyreversescoldhyperalgesia.
- BiologicalactionAntagonist
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname4-(4-Chlorophenyl)-3-methyl-3-buten-2-oneoxime
- MolecularWeight209.67
- Chemicalstructure
![AP 18 [55224-94-7]](images/hellobio/201710/hb1157.png "AP 18 [55224-94-7]")
- MolecularFormulaC11H12ClNO
- CASNumber55224-94-7
StoringandUsingYourProduct
- Storageinstructions+4°C
- SolubilityoverviewsolubleinDMSO(100mM)orethanol(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforAP18
AroleofTRPA1inmechanicalhyperalgesiaisrevealedbypharmacologicalinhibition.
PetrusMetal(2007)MolPain3:40PubMedID:18086313Nitrooleicacid,anendogenousproductofnitrativestress,activatesnociceptivesensorynervesviathedirectactivationofTRPA1.
Taylor-ClarkTEetal(2009)MolPharmacol75(4):820-9.PubMedID:19171673OximederivativesrelatedtoAP18:AgonistsandantagonistsoftheTRPA1receptor.
DefalcoJetal(2010)BioorgMedChemLett20(1):276-9.PubMedID:19945872
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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