Hello Bio/AMTB hydrochloride/HB1167/25mg
商品编号：
HB1167-5mg
品牌：
hellobio
市场价：
¥916.50
美元价：
705.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameAMTBhydrochloride
- ShortdescriptionTRPM8channelblocker
- BIOLOGicaldescriptionTRPM8channelblocker(pIC50=6.23).ExhibitsselectivityforTRPM8channelsoverTRPV1andTRPV4channels.Displaysantiproliferativeproperties.
- BiologicalactionBlocker
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameN-(3-Aminopropyl)-2-[(3-methylphenyl)methoxy]-N-(2-thienylmethyl)benzamidehydrochloride
- MolecularWeight430.99
- Chemicalstructure
![AMTB hydrochloride [926023-82-7]](images/hellobio/201710/hb1167.png "AMTB hydrochloride [926023-82-7]")
- MolecularFormulaC23H26N2O2S.HCl
- CASNumber926023-82-7
- PubChemidentifier16095383
- SMILESCC1=CC(=CC=C1)COC2=CC=CC=C2C(=O)N(CCCN)CC3=CC=CS3.Cl
- InChiInChI=1S/C23H26N2O2S.ClH/c1-18-7-4-8-19(15-18)17-27-22-11-3-2-10-21(22)23(26)25(13-6-12-24)16-20-9-5-14-28-20;/h4-5,7-11,14-15H,6,12-13,16-17,24H2,1H3;1H
- InChiKeyUDXGBANGPYONOK-UHFFFAOYSA-N
StoringandUsingYourProduct
- StorageinstructionsRoomtemperature(desiccate)
- SolubilityoverviewSolubleinwater(100mM)andinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforAMTBhydrochloride
TRPM8ionchannelsdifferentiallymodulateproliferationandcellcycledistributionofnormalandcancerprostatecells.
ValeroMLetal(2012)PLoSOne7(12):e51825.PubMedID:23251635AMTB,aTRPM8channelblocker:evidenceinratsforactivityinoveractivebladderandpainfulbladdersyndrome.
LashingerESetal(2008)AmJPhysiolRenalPhysiol295(3):F803-10.PubMedID:18562636HumanTRPM8andTRPA1painchannels,includingagenevariantwithincreasedsensitivitytoagoNISTs(TRPA1R797T),exhibitdifferentialregulationbySRC-tyrosinekinaseinhibitor.
MorganKetal(2014)BiosciRep34(4):PubMedID:24975826
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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